In the clinical management of diabetes, the A1C assay has become indispensable. Used worldwide to monitor chronic glycemia, the assay is an essential tool to determine whether a patient has achieved the core goal of therapy for diabetes: a marked and sustained reduction in plasma glucose to achieve as close to a normal level as can be safely attained. With the publication of the A1c-Derived Ave...

Andreas Vesalius's great anatomical treatise De humani corporis fabrica (1543) still awaits translation into an accessible modem language, and an English version which makes available to Latinless readers even a small part of the remarkable scholarship of this work will command much attention. The sections dealing with the larynx have been translated by D. H. Garrison and M. H. Hast, and their ...

The Business Process Modelling Notation (BPMN) is a graphoriented language in which control and action nodes can be connected almost arbitrarily. It is supported by various modelling tools but so far no systems can directly execute BPMN models. The Business Process Execution Language for Web Services (BPEL) on the other hand is a mainly block-structured language supported by several execution p...

Appropriately designed and conducted research is necessary for improving patient care and optimizing health outcomes, but access to best evidence is not enough to make these things happen. In respiratory care, as in other fields, patients do not benefit as much as they should from research findings and evidence-based practice guidelines. Current standards for the diagnosis, staging, and managem...

We present a novel framework for mapping between any combination of XML and relational schemas, in which a high-level, userspecified mapping is translated into semantically meaningful queries that transform source data into the target representation. Our approach works in two phases. In the first phase, the high-level mapping, expressed as a set of inter-schema correspondences, is converted int...

VIRUSES THAT DEFY HOST IMMUNE RESPONSES AND PERSIST OR RECUR TAKE A HUGE TOLL ON GLOBAL human health. Many of these, including HIV-1, infl uenza viruses, and several fl aviviruses (such as dengue, hepatitis C, and West Nile virus) rapidly proliferate, frequently mutate, and evolve highly variable surface structures. The effectiveness of such immune escape mechanisms has thwarted multiple attemp...

The human body is more than the sum of its organs. Yet for hundredsof years,medicine andmedical research have divvied up the totality of the person into diseases that are organ specific and characterized largely by their phenotypic presentation. These divisions are also reflected in the organization of academic medical centers and pharmaceutical research and development and even permeate the fu...

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn ...

In rst approximation Core Facile is a simply typed-calculus enriched with parallel composition, dynamic channel generation, and input-output synchronous communication primitives. In this paper we explore the (dynamic) semantics of core Facile programs. This should be taken as a basis for the deenition of abstract machines, the transformation of programs, and the development of modal speciicatio...

XML (eXtensible Markup Language) transformations and queries are crucial operations for interpreting XML databases. XSLT (eXtensible Stylesheet Language Transformations) is a prominent XML technology for these operations, but XQuery (XML Query Language) can query a broad spectrum of XML information sources, including both databases and documents. In this paper, we present our approach to transl...