Recombinant modified vaccinia virus Ankara (MVA) has been used to deliver vaccine candidate antigens against infectious diseases and cancer. MVA is a potent viral vector for inducing high magnitudes of antigen-specific CD8+ T cells; however the cellular immune responses to a recombinant antigen in MVA could be further enhanced by increasing transgene expression. Previous reports showed the impo...

Background and Aims: Retinitis pigmentosa (RP) is the most common form of inherited retinal degeneration, photoreceptors loss of which in the retina causes visual loss. The purpose of the present study was to determine patterns of inheritance in RP patients in Yazd to help the health professional for designing suitable laboratory testing for the high risk families. Materials and Methods: Thirt...

of loss of function of paternal and maternal allele-specific genes, respectively (Dittrich et al., 1996). Many imprinted genes here, including SNRPN, are unmethylated on the paternal chromosome but methylated on the maternal chromosome. Mutations within the SNRPN exon 1 region cause PWS, and those that occur further upstream and affect certain RNA (BD) transcripts cause AS. The imprinting cente...

Wounding ¡sa prerequisite for tumor formation in \-jun transgenic mice. The progression from wound to dermal sarcoma is a multistep process which, at some stage, results in an increase in transgene mRNA expression in tumor tissue. However, transgene expression in individual sarcoma cells stained for Jun protein cultures is heterogeneous. We cloned several cell lines from wound-related \-jun tr...

Wounding is a prerequisite for tumor formation in v-jun transgenic mice. The progression from wound to dermal sarcoma is a multistep process which, at some stage, results in an increase in transgene mRNA expression in tumor tissue. However, transgene expression in individual sarcoma cells stained for Jun protein cultures is heterogeneous. We cloned several cell lines from wound-related v-jun tr...

Genetically transformed insect pests provide significant opportunities to create strains for improved sterile insect technique and new strategies based on conditional lethality. A major concern for programs that rely on the release of transgenic insects is the stability of the transgene, and maintenance of consistent expression of genes of interest within the transgene. Transgene instability wo...

in general, both common illnesses and rare diseases can develop in people and their relatives in families. therefore, taking family history is an effective screening tool to detect such diseases and patients should be aware of its importance in families’ health with updating information in regular visiting. for more information on identifying the genetic pattern of diseases, in this article, we...

two barley (hordeun vulgare l.) genotypes, radical and cwb, with good to moderate levels of resistance to powdery mildew were crossed with a highly susceptible cultivar (afzal) to determine the genetics of resistance. the parents, fl, f2 and f3 generations of each of the two crosses, were evaluated for powdery mildew resistance in the glasshouse and field at the college of agriculture in karaj ...

We present an approach to component inheritance and reuse which closes the gap between architectural design and process-oriented approaches. To apply inheritance checks in design and verification of a system, one should consider an inheritance relation as a property of the system and specify it as an inheritance constraint. To specify the inheritance constraints we offer a logic of behavioural ...

Instability of transgene expression in plants is often associated with complex multicopy patterns of transgene integration at the same locus, as well as position effects due to random integration. Based on maize transposable elements Activator (Ac) and Dissociation (Ds), we developed a method to generate large numbers of transgenic barley (Hordeum vulgare var Golden Promise) plants, each carryi...