Two nitro-substituted 1,4-distyrylbenzene-like compounds have been investigated using stationary and time-resolved (ns/fs) spectrometric techniques as a function of solvent polarity. In the two compounds the central benzene ring is substituted with a p-nitrostyryl group at one side while, at the other side, compound 1 (asymmetric) bears a pyrid-4-ylethenyl group and compound 2 (symmetric) anoth...

With the current high level of interest in patches to deliver drugs across the skin, the concept of external applications for delivery of medicinal substances is becoming widely accepted. This study evaluated the potential for transdermal absorption of castor oil, a treatment modality recommended by Edgar Cayce. Specific epoxydicarboxylic acids are known to be excreted via the urine when castor...

The efficacy of oral aspirin treatment in the secondary prevention of cardio and cerebro vascular disease is well known. However oral administration is often associated with abdominal discomfort. The feasibility of delivering aspirin transdermally from eudragit and polyvinyl acetate (PVA) matrix-type patches to enhance its antithrombotic efficiency of aspirin was investigated. Transdermal films...

Over many millennia, natural products were the only means for food, to treat diseases and injuries. Recently in the field of pharmaceutical sciences great efforts are being directed towards herbal drugs by incorporating them in already existed drug delivery system to solve the problem related to poor solubility, poor bioavailability, dosing problem, stability, toxicity etc. Curcumin is a yellow...

conclusions: although both pain killing therapeutic regimens are safe and effective for postoperative pain management, regarding the easy usage of the patches, lower risk of abuse and cost-effectiveness in the iranian market, it is recommended for use in iranian hospitals and trauma centers and in countries with similar socioeconomic situations. background: acute and severe pain is common in pa...

Effective pain relief is an essential component of a patient's peri-operative care package. Good analgesia has been shown to reduce the incidence of cardiovascular, respiratory and thrombo-embolic complications following surgery. Satisfactory analgesia facilitates early patient ambulation following surgery, which may reduce in-patient stay. Patient-controlled analgesia (PCA) systems are a well ...

The aim of this study was to investigate the effects of different ester groups in position 5' of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared by reaction of stavudine with six different acid chlorides at room temperature. Female human abdominal skin was used for in vitro penetration in Franz diffusion cells. The e...

The body of scientific literature on transdermal alcohol testing dates back almost 70 years. The first viable method enabling this knowledge appeared in the 1980s in the form of an alcohol “sweat-patch”. Recently, transdermal alcohol monitoring bracelets have been used to measure transdermal vapor alcohol. Based on published research in this field, one can conclude that measuring alcohol transd...

Development of controlled release transdermal dosage form is a complex process involving extensive research. Transdermal patches have been developed to improve clinical efficacy of the drug and to enhance patient compliance by delivering smaller amount of drug at a predetermined rate. This makes evaluation studies even more important in order to ensure their desired performance and reproducibil...

Proniosomes are well documented for transdermal drug delivery and preferred over other vesicular systems because they are biodegradable, biocompatible, non-toxic, possess skin penetration ability and prolong the release of drugs by acting as depot in deeper layers of skin. The purpose of the current study was to investigate the feasibility of proniosomes as transdermal drug delivery system for ...