Humulones and iso-humulones are potent natural antioxidants found in beer. In this study, density functional theory (DFT) method was applied for elucidating the structure-antioxidant activity relationship molecular mechanism of antioxidant eight bioactive humulones previously identified different beer samples: isoxanthohumol, (R)- (S)-adhumulone, cis- trans-iso-adhumulone, trans-iso-n-humulone,...

OBJECTIVE Scientific research is constantly striving to find molecules which are effective against excessive body fat and its associated complications. Taking into account the beneficial effects that resveratrol exerts on other pathologies through miRNA, the aim of the present work was to analyze the possible involvement of miRNAs in the regulation of adipogenic transcription factors peroxisome...

Background: The present study investigated the functional maturity of oligodendrocyte derived from rat bone marrow stromal cells (BMSC). Methods: The BMSC were isolated from female Sprague-Dawley rats and evaluated for different markers, such as fibronectin, CD106, CD90, Oct-4 and CD45. Transdifferentiation of OLC from BMSC was obtained by exposing the BMSC to DMSO and 1 µM all-trans-retinoic a...

The Ca-independent immunoglobulin-like molecule nectin first forms cell-cell adhesions and then assembles cadherin at nectin-based cell-cell adhesion sites, resulting in the formation of adherens junctions (AJs). Afadin is a nectinand actin filament-binding protein that connects nectin to the actin cytoskeleton. Here, we studied the roles and modes of action of nectin and afadin in the formatio...

Background: The post-harvesting process of medicinal plants such as drying operation and storage conditions has great influence on their quality and quantity of the active ingredients. Objective: The aim of this experiment was to investigate the effect of pre-drying operation and also storage conditions and duration on the essential oil content and composition of Thymus daenensis. Methods: A ...

In order to investigate the medicinal species from montain of ShirKooh (Up village), in Yazd provience, Iran on three species by scientific names were Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall.; Ziziphora clinopodioides Lam. and Nepeta asterotricha Rech.f. were collected on June, July and August 2011. Then all samples essential oils were extracted by hydro-distillation method (cla...