The hemodynamic findings in five patients with congenital mitral stenosis, four of whom resided at mild altitude (5,200 to 6,500 feet) are presented. Pulmonary hypertension was present in all patients. Reactivity of tbe pulmonary vascular bpd was noted in the four patients residing at altitude. The administration of tolazoline and/or 100 percent 0 2 to three patients resulted in an average drop...

Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ensures chromosome segregation occurs with high fidelity. In all three kinases, kinetochore docking is mediated by the N-terminal region of the protein. Deletions within this regio...

The long-term hemodynamic effects of a high dietary sodium intake were studied in 10 young normal subjects. After a 4-day diet of 10mEq of sodium and 60 mEq of potassium per day the mean arterial blood pressure (MAP) was 82.3 +/- 15.1 mmHg, the cardiac index (CI) was 2.32 +/- 0.69 liter/min/m2, and total peripheral resistance (TPR) was 1778 +/- 947 dyne sec cm-5. After 4 to 6 days of 200 mEq of...

Twenty-four trained, conscious dogs with chronically implanted iliac catheters were used to assess the relative roles of sodium (Na) and volume in the development of mineralocorticoid hypertension. All were maintained on restricted Na diets; supplemental Na was given as slow I.V. infusions of 0.9% NaCl solution. The effect of gradual replenishment of total body sodium on arterial blood pressure...

After each spliceosome cycle, the U4 and U6 snRNAs are released separately and are recycled to the functional U4/U6 snRNP, requiring in the mammalian system the U6-specific RNA binding protein p110 (SART3). Its domain structure is made up of an extensive N-terminal domain with at least seven tetratricopeptide repeat (TPR) motifs, followed by two RNA recognition motifs (RRMs) and a highly conser...

UNLABELLED α2- and β-adrenoceptors (AR) reciprocally control catecholamine release and vascular tension. Disorders in these functions are present in spontaneously hypertensive rats (SHR). The present study tested if α2AR dysfunctions resulted from altered α2AR/βAR interaction. Blood pressure (BP) was recorded through a femoral artery catheter and cardiac output by an ascending aorta flow probe....

Leg crossing increases arterial pressure and combats symptomatic orthostatic hypotension in patients with sympathetic failure. This study compared the central and cerebrovascular effects of leg crossing in patients with sympathetic failure and healthy controls. We addressed the relationship between MCA Vmean (middle cerebral artery blood velocity; using transcranial Doppler ultrasound), frontal...

Calcium is essential for pollen germination and pollen tube growth. A large body of information has established a link between elevation of cytosolic Ca(2+) at the pollen tube tip and its growth. Since the action of Ca(2+) is primarily mediated by Ca(2+)-binding proteins such as calmodulin (CaM), identification of CaM-binding proteins in pollen should provide insights into the mechanisms by whi...

The hemodynamic basis of neurogenic hypertension was studied in unanesthetized rabbits 10 minutes to 30 days after sinoaortic denervation (SAD). The fractional distribution of "Rb to body tissues was determined and used to calculate regional blood flow from the value of cardiac output obtained from an arterial dilution curve of the indicator. Sham-operated rabbits served as controls. Increased ...

In mammography, the efficacy of computer-aided detection methods depends, in part, on the robust localisation of microcalcifications (μC). Currently, the most effective methods are based on three steps: 1) detection of individual μC candidates, 2) clustering of individual μC candidates, and 3) classification of μC clusters. Where the second step is motivated both to reduce the number of false p...