نتایج جستجو برای: tpa therapy
تعداد نتایج: 659243 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE We investigated whether administration of edaravone, a free radical scavenger, before or during tissue-type plasminogen activator (tPA) can enhance early recanalization in a major arterial occlusion. METHODS The YAMATO study (Tissue-Type Plasminogen Activator and Edaravone Combination Therapy) is an investigator-initiated, multicenter (17 hospitals in Japan), prospectiv...
BACKGROUND AND PURPOSE Our aim was to describe an expanded experience with endovascular mechanical embolectomy in a broad group of patients, including those not meeting entry criteria for the MERCI multicenter trials. METHODS We performed an analysis of all patients with ischemic stroke treated with the Merci Clot Retrieval Device at a single academic center outside of the Mechanical Embolus ...
BACKGROUND AND PURPOSE Increasing thrombus length (TL) impedes recanalization after intravenous (IV) thrombolysis. We sought to determine whether the clinical benefit of aspiration thrombectomy relative to IV r-tPA (recombinant tissue-type plasminogen activator) may be greater at longer TL. METHODS THERAPY was a randomized trial of aspiration thrombectomy plus IV r-tPA versus IV r-tPA alone i...
The iScore is a validated tool to estimate outcomes after an acute ischemic stroke. A previous study showed the iScore can predict clinical response and risk of intracerebral hemorrhage (ICH) after administration of tissue plasminogen activator (tPA). We applied the iScore (www.sorcan.ca/iscore) to participants in the National Institute of Neurological Disorders and Stroke tPA stroke trials to ...
Approximately half of acute ischemic stroke patients end up with a disability that interferes with independent living, despite treatment with intravenous tissue plasminogen activator (iv. tPA). One of the strongest explanations is the low rates of full and sustained recanalization at the arterial occlusion site with iv. tPA alone. This prompted the search for adjunctive therapies to achieve rec...
Time-dependent density functional theory (TD-DFT) is applied to model one-photon (OPA) and two-photon (TPA) absorption spectra in a series of conjugated cytotoxic dyes. Good agreement with available experimental data is found for calculated excitation energies and cross sections. Calculations show that both OPA and TPA spectra in the molecules studied are typically dominated by two strong peaks...
BACKGROUND AND PURPOSE Tools to predict the clinical response after intravenous thrombolytic therapy (tPA) are scarce. The iScore is an existing validated tool to estimate outcomes after an acute ischemic stroke. The purpose of this study was to determine the ability of the iScore to predict clinical response and risk of hemorrhagic transformation after tPA. METHODS We applied the iScore (www...
Introduction: Osteoporosis is a bone disease in which there is a reduction in the amount of bone mineral content leading to an increase in the risk of bone fractures. The affected individuals not only have to go through lots of pain and suffering but this disease also results in high economic costs to the society due to a large number of fractures. A timely and accurate diagnosis of this disea...
Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). Rates of favourable outco...
See related article, pages 993–997. Sixteen years after the results of The National Institute of Neurological Disorders and Stroke rtPA Stroke Study, intravenous alteplase (IV tissue plasminogen activator [tPA]) is still the unique recommended therapy for patients with acute ischemic stroke.1 Since 1995, no other acute stroke therapy has replaced this gold standard, but is IV tPA really a silve...
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