background: ( h.pylori ) infection is a common bacterial infection in humans. approximately half of the helicobacter pylori people throughout the world are infected by this gastric microbial pathogen. the outcome of h.pylori infection varies from gastritis to peptic ulcers, duodenal ulcers and gastric malignancies. this study aims to estimate the prevalence of h.pylori infection and iron defici...

OBJECTIVE Iron and the iron regulatory hormone hepcidin, major determinant of body iron distribution, are hypothesized to play a role in cardiovascular disease. Here, we assess the associations of hepcidin as well as ferritin, iron, total iron-binding capacity, and transferrin saturation (ie, iron parameters) with noninvasive measurements of atherosclerosis in men and women of a population-base...

The optimal acid-base status for survival in maintenance hemodialysis (MHD) patients remains controversial. According to recent reports, acidosis is associated with improved survival in MHD patients. It was hypothesized that this inverse association is due to a confounding effect of the malnutrition-inflammation complex syndrome (MICS). Associations between baseline (first 3 mo averaged) predia...

The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampu...

OBJECTIVES An increase in serum ferritin and levels of the cleaved soluble form of transferrin receptor (sTfR) are related to several metabolic conditions. We evaluated the relationship between body iron status indicators, including ferritin and sTfR, and insulin resistance and metabolic syndrome (MetS) in Korean children. METHODS A cross-sectional study was conducted on 1350 children in Kore...

The patient is a 40-year-old Caucasian obese man who was diagnosed with hereditary hemochromatosis in November of 2004. He originally presented with fatigue and underwent blood testing that showed a serum iron level of 128mg/dl (22.91 mmol/l), a total iron-binding capacity (TIBC) of 307mg/dl (54.9 mmol/l), a ferritin value of 733 ng/ ml (1647 pmol/l) and an iron saturation of 42%. The patient h...

BACKGROUND Patients with chronic HCV infection have increased liver iron. Recently identified protein hepcidin synthesized in the liver, is thought to be a key regulator for iron homeostasis and is induced by infection and inflammation. Lower erythropoietin and iron supplementation requirements were previously reported in HD patients with HCV infection. We investigated the association of prohep...

Picolinic acid, a metal chelating molecule, was administered to human erythroleukaemic cell lines (K 562 and HEL) that were grown in serum-containing media. Picolinic acid inhibited both iron uptake and cell growth. Furthermore, picolinic acid was shown to markedly decrease the level of ferritin in the cells. In spite of the inhibition of cell growth, picolinic acid induced a marked increase in...

background cardiovascular disease is the world´s leading cause of death and elevated serum iron and ferritin have been proposed as a risk factor for acute myocardial infarction (ami) in recent years. this study was done to determine the relationship between serum iron and ferritin with ami and its role on early coronary vessels disorder. material and methods in this cross-sectional study, total...

Objective: To determine iron bioavailability in obese subjects after the ingestion of a nutritional supplement containing multiple nutrients. Methods: Fourteen persons were studied before and after bariatric surgery after the ingestion of a nutritional formulation containing 25 mg iron, 25 g fiber and 800 mg calcium. Serum iron levels were measured basally and every hour after the ingestion of ...