The ability to manage non-melanoma skin cancers and pre-malignant lesions with topical pharmacologic agents is highly compelling. This article examines currently available products and discusses their emerging roles and limitations. These include fluorouracil, diclofenac sodium, imiquimod, and photodynamic therapy.

Bowen's disease (squamous cell carcinoma in situ) has a 3%-5% risk to develop into invasive squamous cell carcinoma. Non-melanoma skin cancer is the most common cancer among Caucasians and its incidence has increased during the last decades dramatically. Multiple treatment options for Bowen's disease have been described and are established with advantages and disadvantages. Bowen's disease occu...

The glycosaminoglycan hyaluronic acid (HA), or hyaluronan, is a major component of the extracellular matrix of skin, joints, eye and many other tissues and organs. In spite of its simple structure, HA demonstrates remarkable rheological, viscoelastic and hygroscopic properties which are relevant for dermal tissue function. Biological activities in skin, however, are also due to its interaction ...

1. Abstract: A new, simple, precise, accurate and selective high performance thin-layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of Tolperisone hydrochloride and Diclofenac sodium in a tablet dosage form. Chromatographicseparation was carried out on Merck TLC aluminium sheets of silica gel 60F254 using Toluene: Ethyl acetate: Methanol (4...