Description: Fluoride dentifrices were first introduced in the 1950s. [1] The first fluoride dentifrice contained stannous fluoride and was first marketed in 1955. Since then many studies have investigated the level of dose and the form of fluoride that is optimum in dentifrice formulations. Higher caries reduction was reported in the 70s in clinical trials that investigated the potency of usin...

Various authors have shown that the caries decline in the industrialized countries during recent decades is based on the use of fluorides, of which local fluoride application in the form of fluoridated toothpastes is of primary importance. The caries-protective potential of fluorapatite is quite low; in contrast, dissolved fluorides in the vicinity of enamel are effective both in promoting remi...