نتایج جستجو برای: tol
تعداد نتایج: 1843 فیلتر نتایج به سال:
The role of hydrogen bond acidity, i.e., the ability of chemicals to act as hydrogen bond donors (HBD), is a crucial element in pharmaceutical sciences and medicinal chemistry. It has been shown that the difference between logP values (ΔlogP) obtained in two different biphasic systems is informative of the solutes HBD properties and thus useful in the prediction of drugs human fate. In this stu...
BACKGROUND Individuals who rapidly develop hyperthermia during heat exposure (heat-intolerant) are vulnerable to heat associated illness and injury. We recently reported that heat intolerant mice exhibit complex alterations in stress proteins in response to heat exposure. In the present study, we further explored the role of genes and molecular networks associated with heat tolerance in mice. ...
The lymphocyte toxicity assay (LTA) is a proposed surrogate marker of sulfonamide antibiotic hypersensitivity. In the LTA, peripheral blood mononuclear cells (PBMCs) undergo apoptosis more readily in hypersensitive versus tolerant patients when exposed to drug-hydroxylamine metabolites in vitro. The purpose of this study was to identify key gene transcripts associated with increased cytotoxicit...
Successful induction of allograft tolerance has been achieved in nonhuman primates (NHPs) and humans via induction of transient hematopoietic chimerism. Since allograft tolerance was achieved in these recipients without durable chimerism, peripheral mechanisms are postulated to play a major role. Here, we report our studies of T cell immunity in NHP recipients that achieved long-term tolerance ...
Eleven iron(II) 1D coordination polymers with the general formula [FeLeq(Lax)]· solvent were synthesised and characterised, where Leq = {diethyl (E,E)-2,2′-[1,2-phenylbis(iminomethylidyne)]bis[3-oxobutanoate] (2-)-N,N′,O,O′} (L1) and {3,3′-[1,2-phenylbis(iminomethylidyne)]bis[pentane-2,4-dione] (2-)-N,N′,O,O′} (L2); Lax = 4,4′-bipyridine (bipy), 1,2-bis(4-pyridyl)ethane (bpea) and 1,3-bis(4-pyr...
Chemometrics-assisted UV spectrophotometric and RP-HPLC methods are presented for the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) from their combined pharmaceutical dosage form. Chemometric methods are based on principal component regression and partial least-square regression models. Two sets of standard mixtures, calibration sets, and validation s...
Only recently has there been any consideration of the influence of the problem structure on Tower of London task (TOL) performance. Not surprisingly, these few studies that have investigated this issue have found significant differences in the cognitive demands of individual TOL problems. Based on these previous findings, the aim of the current study was to further explore the effects of two pr...
Abstract We develop an adaptive algorithm for large SDE systems, which automatically selects (quasi-)deterministic time steps the semi-implicit Euler method, based on a posteriori weak error estimate. Main tools to construct estimator are representation of approximation via Kolmogorov’s backward equation, priori bounds its solution and Clark–Ocone formula. For certain class we validate optimal ...
Wietse Tol and colleagues discuss some of the key challenges for implementation of new WHO guidelines for stress-related mental health disorders in low- and middle-income countries. Please see later in the article for the Editors' Summary.
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید