Among the geometrical isomers of vitamin A and retinene, the neo-b isomer occupies a special position. As the precursor of rhodopsin and iodopsin, it plays a central r81e in rod and cone vision (1, 2). It is stored almost exclusively in the eyes of certain Crustacea (3) and is equally distinctive chemically. The four unhindered geometrical isomers of vitamin A have been identified (4, 5); neo-b...

The aim of this study was to investigate the behavior of the protonated paralytic shellfish poisons saxitoxin (STX) and neosaxitoxin (NEO) in the gas-phase after ion activation using different tandem mass spectrometry techniques. STX and NEO belong to a group of neurotoxins produced by several strains of marine dinoflagellates. Their chemical structures are based on a tetrahydropurine skeleton ...

Emerging evidence suggest that the heterogeneity of cancer limits the efficacy of immunotherapy. To search for optimal therapeutic targets for enhancing the efficacy, we used whole-exome sequencing data of 23 early cervical tumors from Chinese women to investigate the hierarchical structure of the somatic mutations and the neo-epitopes. The putative neo-epitopes were predicted based on the muta...

Planning systems such as FF-Metric [3] and SAPA [2] are able to deal with numerical knowledge to solve resources constraints added to the symbolic planning domain. This paper presents the NGP (Numerical Graph Planning) that is able to solve totally numerical and/or symbolic planning domains. We propose a new action representation to support numerical conditions and effects, where we allow a non...

The aim of this study is to propose a method for the evaluation of railway passengers’ comfort in relationship to temperature, noise, and vibration. Estimated the single comfort for every sensation considered, the global comfort is evaluated with the Hyper-Sphere Method proposed by Corriere & Lo Bosco [1]. The humanvehicle-infrastructure-environment variables which influence comfort are individ...

The aim of this study was to analyse the psychometric properties of the Spanish NEO Five Factor Inventory-Revised (NEO-FFI-R) using Rasch analyses, in order to test its rating scale functioning, the reliability of scores, internal structure, and differential item functioning (DIF) by gender in a psychiatric sample. The NEO-FFI-R responses of 433 Spanish adults (154 males) with an anxiety disord...

This study presents new analyses of NEO Personality Inventory-Revised (NEO-PI-R) responses collected from a large British sample in a high-stakes setting. The authors show the appropriateness of the five-factor model underpinning these responses in a variety of new ways. Using the recently developed exploratory structural equation modeling (ESEM) technique, the authors show that model fits impr...

OBJECTIVE To explore the value of transrectal ultrasonography (TRUS) for tumor node metastasis (TNM) restaging for patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy (neo-CRT). METHODS One hundred and forty-nine patients with locally advanced rectal cancer (cT3-4 or cN+) who underwent TRUS after neo-CRT were retrospectively reviewed. TRUS restaging was compared w...

No collection of laws from the iNeo-Assyrian period is known to us. If a text of this kind had ever existed, it seems highly likely that it would have been part of Assurbanipal's famous library in Nineveh. But neither in Nineveh nor in twenty-three excavated sites located in different parts of the empire have archaeologists have succeeded in unearthing so much as a fragment of such a text. In a...

Introduction. The notion of a division ring can be generalized to give a system whose addition is not necessarily associative, but which retains the property of coordinatizing an affine plane. Such a system will be called a planar division neo-ring (PDNR); examples of (infinite) PDNRs which are not division rings are known. If (R, +, •) is a finite power-associative PDNR, then (R, +) is shown t...