Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution of inflammation is incompletely characterized. Nanoparticles are known to induce plasma membrane damage and necrosis followed by sterile inflammation. We observed that injection of metabolically inert nanodiamonds resulted in pa...

used in the treatment of various tumors. Retinoic acid has potent antioxidant effects. In this study, it is aimed to reveal effects all-trans retinoic (ATRA) on CP induced cardiotoxicity.
 Materials and Methods: wistar albino rats were used. Control group received single daily doses 1 ml/kg saline ATRA ATRA(7,5mg/kg/day) intraperitoneally (i.p.) for 10 days. ATRA+CP a dose CP(7mg/kg) i.p. ...

Bovine mastitis, caused by Prototheca bovis, has received much attention worldwide. To investigate the status of P. bovis infection in dairy farms Hubei, we collected 1,158 milk samples and 90 environmental from 14 China. The isolates were identified with traditional biological methods molecular techniques, their pathogenicity was tested through mice experiments. Isolates 57 20 as bovis. tests ...

Autopsies and pathology findings can enhance understanding of processes that occur while a person is still alive. Hence, wound care clinicians from all disciplines can learn about pressure-related injury from necrosis research performed on decedents by forensic pathologists. The current system of pressure ulcer staging and assessment is unidimensional and contains many gaps, leading to variatio...

Ischaemic insult in the skin flaps is a major problem in reconstructive surgery particularly in patients with diabetes mellitus. Here, we sought to investigate the effectiveness of ischaemic preconditioning (IP) on diabetic skin flaps in rat animal model. Hundred Wistar rats (90 streptozotocin treated animals and 10 nondiabetic controls) were used. Diabetes mellitus was confirmed by measuring g...

Inadvertent leakage of medications with vesicant properties can cause severe necrosis in tissue, which can have devastating long-term consequences. The aim of this study was to evaluate the extent of extravasation injury induced by thiopental and propofol, and the effects of cooling or warming of local tissue on extravasation injury at macroscopic and histopathologic levels. Rats were administe...

premixed non-setting calcium hydroxide (caoh 2 ) paste in pressure syringe system is commonly used in root canal therapy. the aim of this paper is to present a case involving an iatrogenic extrusion of the medicament during endodontic treatment and a literature review of similar reports. the present case demonstrates severe tissue necrosis and other deleterious effects following the extrusion o...

in this study, cadmium (cd) accumulation was studied in an experimental aquatic exposure. mosquitofish (gambusia affinis) were acutely exposed for 96 h to a high concentration of cd (12 mg/l) and were chronically exposed to a low concentration of cd(0.4 mg/l) for 30 days. cd accumulation profiles differed between the two cd exposures. the cd concentation in g. affinis tissues increased linearly...

abstract tomato spotted wilt virus (tswv) was detected in tomato leaf and fruit samples collected from viiramin reyion in tehran province using indicator test plants including petunia hybrida, nicatiana glutinosa, n. tabacum cv. snmsun nn, n. clevelandit and n. benthamiana and seroloyical tests. small browinsh local necrotic lesions appeared on p. hybrida leaves 2-4 days post-inoculation. syste...

radiation-related wounds challenge surgeons in all disciplines of surgery. wound-healing complications are commonplace, and solutions for reconstruction are limited. muscle and musculocutaneous flaps have improved this situation. but the question is, does previous radiation of the muscle to be transposed affect the outcome? 143 consecutive previously irradiated patients treated with muscle or m...