background: bone tissue engineering requires materials that are biocompatible, mechanically suited for bone function, integrated with the host skeleton, and support osteoinduction of the implanted cells for new bone formation. the aim of this study was to compare the osteogenic potential of xenograft with hydroxyapatite/β- tricalcium phosphate (ha/β-tcp) scaffold. methods: new zealand rabbits (...

background: adipose-derived stem cells (adsc) could be an appealing alternative to bone marrow stem cells (bmsc) for engineering cell-based osteoinductive grafts. meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. therefore, we assayed and compared the melatonin effect on osteogenic differentiation of bmsc with that of adsc. methods: mesenchymal ...

in recent years the science of tissue engineering has emerged as a powerful tool for the development of a novel set of tissue replacement parts and technologies. recent advances in the fields of biomaterials, stem cell technologies, growth factor field and biomimetics have created a unique set of opportunities for investigators to fabricate lab-grown tissues from combination of extracellular ma...

the identification of multipotential mesenchymal stem cells (mscs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. this review article focuses on the biology of mscs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering. our current unders...

for the first time we have used eyelid skin expansion to facilitate reconstruction of selected patients with shortage of lid skin (e.g. for burn scar and after excision of tumors). this method allows for a controlled increase in skin, need for reconstruction, and offers many advantages over grafted skin transfered from a distance. color, texture, thinness, delicacy and adnexal structures are ae...

background: in patients with acute ischemic cerebral infarction, thrombolytic therapy using intravenous tissue plasminogen activator (iv?tpa) necessitates precise documentation of symptoms’ onset. the aim of this study was to identify major barriers related to the iv?tpa injection in such patients. materials and methods: between 2014 and 2015, patients with definitive diagnosis of acute cerebra...

hemangiomas of the sinonasal tract are rare, and because these lesions lack the typical signs or symptoms, they can be confused with other malignant conditions. we report a case of cavernous hemangioma of the maxillary sinus in a 68-year-old man that was completely resected by endoscopic sinus surgery. although computed tomography (ct) and magnetic resonance imaging (mri) showed several enhanci...

background tissue engineering is used for the treatment of many diseases, and the ideal cell source for cartilage tissue engineering is chondrocytes. the main limitation of chondrocyte is the low number of cells in cartilage tissue engineering. this study investigated a suitable cell source with high proliferation rate to obtain a large number of chondrocytes. methods adult cartilage tissue sam...

spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spi­nal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...

recurrent dislocation is not common in small joints. this report presents a new case of chronic recurrent dislocation of proximal interphalangeal joint of the finger in which soft tissue injuries have a role in the dislocation. the patient was a 23 years old man who had referred to our center because of recurrent dislocation of proximal interphalangeal joint of his right ring finger during spor...