OBJECTIVE To present two cases with thyrotropin-secreting adenoma and the effectiveness of octreotide acetate treatment on their tumor size as well as on thyroid stimulating hormone (TSH) and thyroid hormone levels. CASE REPORTS The first case presented with tremor, palpitations and sweating as suggestive of hyperthyroidism, but the other one presented with predominantly headache, while the o...

OBJECTIVE Subclinical hypothyroidism occurs in a number of children with Down's syndrome (DS). The reason for the mildly elevated plasma thyrotropin (TSH) concentrations is not known. The present study investigated whether decreased TSH bioactivity plays a role in this phenomenon. DESIGN A retrospective study of plasma specimens from DS children with mildly elevated plasma TSH concentrations ...

To define the sites in the extracellular domain of the human thyrotropin (TSH) receptor that are involved in TSH binding and signal transduction we constructed chimeric thyrotropin-luteinizing hormone/chorionic gonadotropin (TSH-LH/CG) receptors. The extracellular domain of the human TSH receptor was divided into five regions that were replaced, either singly or in various combinations, with ho...

Across taxa, the seasonal transition between non-breeding and breeding states is controlled by localised thyroid hormone signalling in deep brain via reciprocal switching of deiodinase enzyme expression from type 3 (DIO3) to 2 (DIO2). This switch considered be mediated increasing thyroid-stimulating ? (TSH?) release pars tuberalis, which occurs response a change photoperiod. Although well chara...

Physiological production of thyroid hormone requires an intact hypothalamic-pituitary-thyroid (HPT) axis and involves thyroid-stimulating hormone (TSH, or thyrotropin) released from the anterior pituitary gland. TSH stimulates thyroid follicular cells to synthesize, store and release the thyroid hormones thyroxine (T4) and triiodothyronine (T3) [1]. Chemical laboratory testing of thyroid functi...

We report an 11-year-old girl with euthyroid Graves' disease. She was referred to our clinic because of left exophthalmos without other symptoms suggestive of hyperthyroidism. Her serum concentration of free thyroxine (FT4) and free triiodothyronine (FT3) were normal, but thyroid-stimulating hormone (TSH) was below normal and impaired TSH response to TSH releasing hormone (TRH) was found. Altho...

Subclinical hypothyroidism (SCH), also called mild thyroid failure, is diagnosed when peripheral thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone (TSH) levels are mildly elevated. This condition occurs in 3% to 8% of the general population. It is more common in women than men, and its prevalence increases with age. Of patients with SCH, 8...

Chronic kidney disease (CKD) is a widespread condition in the global population and is more common in the elderly. Thyroid-stimulating hormone (TSH) level increases with aging, and hypothyroidism is highly prevalent in CKD patients. However, the relationship between low thyroid function and mortality in CKD patients is unclear. Therefore, we conducted a retrospective cohort study to examine the...

Preliminary data have suggested that female infertility due to corpus luteum insufficiency may be caused by subclinical hypothyroidism [exaggerated thyroid-stimulating hormone (TSH) response to thyrotrophin-releasing hormone (TRH) stimulation]. L-Thyroxine supplementation has been recommended to achieve pregnancies in subclinical hypothyroid women. This controlled study was carried out in order...

Objective: It was to investigate the relationship between high thyrotropin, thyroid stimulating hormone (TSH) degree and changes of low-density lipoprotein cholesterol (LDL-C) in Yunnan Plateau pregnant patients’ serum China; Methods: All woman were collected from Kunming Angel Women's Children's Hospital January 2021 October 2022, who diagnosed by endocrinology department, during their pregnan...