In mature rams, the signs of high functional activity thyroid gland are observed in autumn period. An increase diameter follicles (109.1±0.58 microns) is marked, height epithelium (9.6±0.11 and area thyrocyte nuclei (32.8±0.38 μm2) statistically significant (P<0.001). pituitary rams period, there an number tyrotropes. The cytoplasm tyrotropes filled with secretory granules, which reflects le...

background: the thyroid gland absorbs nearly all the iodine in the blood, independently of its isotopic composition. when a large enough activity of radioactive iodine like 131i, 132i, 133i is taken into the body, it can destroy the healthy thyroid gland cells as well as the cancer’s cells. in fact, as it is well known, some isotopes of iodine are used not only for acquiring thyroid images but ...

Direct development is a widespread, alternative life history in Recent amphibians. There is no free-living, aquatic larva; adult features form in the embryo and are present at hatching. The mechanistic bases of direct development remain relatively unexplored. The current study describes the embryonic ontogeny of the thyroid gland in the direct-developing frog Eleutherodactylus coqui (Leptodacty...

Tumor-node-metastasis is one of the leading causes of morbidity and mortality in thyroid cancer patients. Upregulation of vascular endothelial growth factor-C (VEGF-C) increases the migratory ability of thyroid cancer cells to lymph nodes. Expression of neuropilin-2 (NRP-2), the co-receptor of VEGF-C, has been reported to be correlated with lymph node metastasis in human thyroid cancer. The pre...

Increasing numbers of substances present in the environment are postulated to have endocrine-disrupting effects on vertebrate populations. However, data on disruption of thyroid signaling are fragmentary, particularly at the molecular level. Thyroid hormone (TH; triiodothyronine, T3) acts principally by modulating transcription from target genes; thus, thyroid signaling is particularly amenable...

Purpose: To investigate the impact of quantitative FDG-Metabolic activity of non-iodine avid Loco-regional recurrence [LRR; thyroid recurrence and/or cervical node metastasis] on therapy selection in thyroid cancer patients with elevated thyroglobulin [TG]. Methods: Forty thyroid cancer [33 papillary and 7 follicular] patients who underwent FDG PET/CT were studied [with TSH>30 mU/L]. Those with...

Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy. Now that the molecule that mediates radioiodine uptake, the sodiu...

BACKGROUND There is growing evidence that, in addition to the reproductive system, the hypothalamic-pituitary-thyroid axis is a target of endocrine-disrupting compounds (EDCs). However, this is not reflected adequately in current screening and assessment procedures for endocrine activity that to date determine only general parameters of thyroid function. OBJECTIVE AND METHODS We used several ...

Recently, there has been growing interest in the relationship between allergic and autoimmune diseases. Allergy and autoimmunity can be considered two potential outcomes of dysregulated immunity and analysis of literature data shows a strong positive association between a history of Th2-mediated allergic disorders and Th1-mediated autoimmune disorders.Autoimmune thyroid diseases are the most co...

The long-acting thyroid stimulator (LATS) has been thought to be responsible for the hyperthyroidism of Graves's disease. It is detected by its effect on the mouse thyroid gland but cannot be found in all patients with hyperthyroidism. In an attempt to clarify the problem of LATS-negative hyperthyroidism, serum was obtained from untreated patients and its effect in vitro on human thyroid tissue...