Research data presented in the article are based, mainly, on concept that thymus, together with bone marrow represent central organ of immune system being source all T cell populations that, following their migration from thymus to periphery, participate development response any antigens viral, bacterial and tissue origin, allergens. This difference is principal, as opposed which produces other...

Thymus-derived lymphocytes (T cells) have two outstanding characteristics that distinguish them from other lymphocytes: (a) they express two specificities, one for self-antigens, the major transplantation antigens (H) coded by the major histocompatibility gene complex (MHC), and a second specificity for foreign antigenic determinants. (b) T cells must undergo differentiation or maturation in th...

Cytochrome P450 (P450) monooxygenases play a role in target tissue metabolic activation of xenobiotics and/or endogenous compounds, such as vasoactive molecules or hormones. Indeed, tissue-specific metabolism of steroids is important in a variety of organs, including thymus, and may alter tissue-specific functions. Steroids have been shown to regulate thymus growth and function, but surprisingl...

for developmental study of thymus in different stages offetal period, from thymus glands of75 healthy fetuses. histological sections were prepared and stained by h&e;, pas, verhoeff, toluidine blue and van geisson's methods. this study revealed that, the infiltration and accumulation of lymphocytes in thymus takes place at second month. medullae were expanded and cortices were seen as accu...

The effects of crude thymus extract on the immune response and protection against challenge with virulent infectious bursal disease virus (IBDV) were studied in one-day-old chick. Oral administration of thymus extract (1 ml/kg) markedly and significantly increased the total protein, albumin, globulin, Tri-iodothyronine (T3), Thyroxine (T4) and the body weight gain in one-day-old chick. In addit...

Recently several studies have been made concerning morphological and functional aspects of thymus grafts in mice (METCALF, 1963, 1964; DUKOR, MILLER, HOUSE and ALLEN, 1965; LEUCHARS, CROSS and DUKOR, 1965; MILLER et al., 1966). In these studies, thymuses from neonatal donor mice were usually grafted under the renal capsule of recipients, because grafting at that site offered many advantages as ...

We investigated the role of continuous thymus output in the shaping of mature T cell repertoires by studying in vivo the survival of a single clone of mature Rag2-deficient T cell receptor (TCR) transgenic cells at different stages of activation in the absence or presence of thymus export. In the absence of thymus export, TCR-transgenic lymphocytes survived indefinitely in the peripheral pools....

The establishment of a functional blood vessel network is an essential part of organogenesis, and is required for optimal organ function. For example, in the thymus proper vasculature formation and patterning is essential for thymocyte entry into the organ and mature T-cell exit to the periphery. The spatial arrangement of blood vessels in the thymus is dependent upon signals from the local mic...

Certain biological and pharmacological effects of the Thymus species have been experimentally proved, such the expectorant (1), spasmolytic (1-3), antibacterial (1,4), antifungal (5), antioxidant (6-9), etc. These activities are due to the specific composition of the essential oils (1, 4-9), flavonoids (1-3, 9), phenolic acids (4) and other chemical constituents of Thymus. Beside the data conce...

BACKGROUND Previously, we reported an association between higher maternal polychlorinated biphenyl (PCB) concentrations and smaller thymus volume in newborns in a birth cohort residing in eastern Slovakia. OBJECTIVE In the present report we address whether thymus volume at later ages is influenced by prenatal and early postnatal PCB exposure. METHODS At the time of delivery, 1,134 mother-in...