Thymoma is the most commonly identified cancer in the anterior mediastinum. To date, the causal mechanism that drives thymoma progression is not clear. Here, we generated K5-∆N64Ctnnb1/ERT2 transgenic mice, which express an N-terminal deletion mutant of β-catenin fused to a mutated ligand-binding domain of estrogen receptor (ERT2) under the control of the bovine cytokeratin 5 (K5) promoter. T...

Autoimmune hepatitis (AIH) has rarely been described as an autoimmune paraneoplastic syndrome of thymoma. This case is the seventh case of AIH revealed by cholestasis few years after the diagnosis of thymoma and the first case treated with chemotherapy alone. We report in this paper a new approach to this rare severe condition. A 29 year-old man presented with chest pain and dyspnea with a hist...

Among the many sites of ectopic thymoma development, the middle mediastinum is the rarest in the English language literature we found only two case reports. We present a case of 69-year-old woman with slow-growing, ectopic middle mediastinum thymoma of an very unusual histological type, neither classified in the Müller-Hermelink nor the World Health Organization (WHO) classification.

BACKGROUND Thymoma is the most common tumor of the anterior mediastinum. Surgery is mainstay of treatment, with adjuvant radiation recommended for invasive thymoma. Because of rarity, prospective randomized trials may not be feasible even in multicentric settings hence the best possible evidence can be large series. Till date Thymoma has not been studied in Indian settings. MATERIALS AND METH...

STUDY OBJECTIVES No established curative treatment is available for pleural thymoma metastases and malignant pleural mesothelioma (MPM). Recently, peritoneal malignancies have been treated by cytoreductive surgery and intraoperative hyperthermic intracavitary perfusion chemotherapy (HIPEC). We investigated the feasibility and safety of this multimodality treatment in the thoracic cavity. DESI...

UNLABELLED The aim of the study was to assess factors concurring to fatal outcome of patients operated for thymoma with or without myasthenia gravis. MATERIAL AND METHODS A retrospective observational study was carried out on a series of 10 patients treated for thymoma in the IIIrd Surgical Unit of "St. Spiridon" University Hospital. RESULTS Mean survival time was 4.45 years and mortality r...

We describe a case of recurrent metastatic thymoma showing an excellent response to salvage paclitaxel monotherapy. The patient had undergone a series of platinum-based chemotherapy treatments during the previous 20-month period and the patient's disease was considered resistant to such therapy at the start of treatment with paclitaxel. This is the first report to suggest that paclitaxel has an...

The objective : to determine the indications and possibility of surgical treatment giant malignant intrathoracic tumors. Subjects Methods . authors presents their own experience 19 patients with Results. Overall resectability was 79% (15/19 patients). 4 underwent combined surgery: in 2 patients, tumor removed resection a part upper lobe lung; 1 patient had this left lung resected (pneumoectomy)...

Cytogenetic analysis of mixed lymphocyte and epithelial thymoma in a nonmyasthenic female patient revealed deletion of part of the short arm of chromosome 6. To our knowledge, this cytogenetic abnormality in a benign thymoma has not been previously described in the literature, which is reviewed.

We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is revie...