Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacter...

Aiming to contribute drug pre-formulation, new eutectic mixtures were developed. Thymol, coumarin, or quaternary ammonium chlorides as excipients, combined with the active pharmaceutical ingredients (APIs) acetylsalicylic acid, acetaminophen, ibuprofen, ketoprofen, lidocaine. Their solid-liquid equilibrium (SLE) binary phase diagrams measured study eventual separation between compounds, prevent...

The aim of this research is production disinfection (Dettol) contains herbal formula and study the efficacy it for inhibition pathogenic bacteria as comparing with traditional Dettol efficacy. In research, a disinfectant antiseptic was prepared similarly to industrial in terms composition, except active substance (chloroxylenol), which replaced by plant extract (thyme) compound (thymol) separat...

In 1913 Jolles (1) introduced alcoholic thymol as a reagent for the detection of indican in urine, and later, based upon its use, developed a calorimetric method (2) for the estimation of indican in both urine and blood. His method for urine consisted in adding to 10 cc. of urine filtrate, after clarification with lead acetate, 1 cc. of 5 per cent alcoholic thymol, and 10 cc. of concentrated hy...

Introduction: Thymol has negative ionotropic effect on heart and has direct effect on calcium release from sarcoplasmic reticulum. Some of the herbal plants just like carum copticum consist of thymol. The postganglionic neurons of the gastrointestinal parasympathetic system are located mainly in the myenteric and submucosal plexuses. Stimulation of these parasympathetic nerves causes general...

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was ca...

ABSTRACT- Chrysanthemum (Dendranthema grandiflorum) is one of the most important ornamental plants used as cut flower, flowering pot plant and groundcover worldwide. In this research, the effects of preservative solutions containing thymol (75 and 125 mg -L), menthol (75 and 125 mg L-1) and eugenol (75 and 125 mg L-1) on the quality and vase-life of chrysanthemum cut flowers at 3±1ºC and 75-80%...

Background: Our previous findings indicated that carvacrol and thymol alleviate cognitive impairments caused by Aβ in rodent models of Alzheimer's disease (AD). In this study, the neuroprotective effects of carvacrol and thymol against Aβ25-35-induced cytotoxicity were evaluated, and the potential mechanisms were determined. Methods: PC12 cells were pretreated with Aβ25-35 for 2 h, followed by ...

Cryptococcosis is an emerging and recalcitrant systemic infection occurring in immunocompromised patients. This invasive fungal infection is difficult to treat due to the ability of Cryptococcus neoformans and Cryptococcus laurentii to form biofilms resistant to standard antifungal treatment. The toxicity concern of these drugs has stimulated the search for natural therapeutic alternatives. Ess...

Cough is a phenomenon frequently associated with upper airway diseases and as a reflex is modulated by many afferent inputs either from respiratory tussigenic areas, but also by afferent drive from other organs. Modulation of cough by nasal afferent inputs could either facilitate cough response or inhibit it in animal models, depending on the type of trigeminal afferents which are stimulated. I...