Blunt chest trauma can lead to a variety of cardiac injuries, one of which is nonatherosclerotic myocardial infarction caused by intimal laceration and thrombotic process activation. Here we present a case of anterior myocardial infarction secondary to blunt trauma involving a kick to the chest.

Almost 80 years after Eli Moschcowitz published the first description of the disease, most patients with idiopathic thrombotic thrombocytopenic purpura (TTP) were found to have acquired autoantibody inhibitors of the ADAMTS13 metalloprotease. Plasma ADAMTS13 normally cleaves von Willebrand factor within nascent platelet-rich thrombi, and ADAMTS13 deficiency allows unchecked thrombus growth to c...

Prevailing approaches to manage autoimmune thrombotic disorders, such as heparin-induced thrombocytopenia, antiphospholipid syndrome and thrombotic thrombocytopenic purpura, include immunosuppression and systemic anticoagulation, though neither provides optimal outcome for many patients. A different approach is suggested by the concurrence of autoantibodies and their antigenic targets in the ab...

BACKGROUND Compared with the general population, cancer patients have a higher risk of venous thromboembolism as well as arterial thrombotic events such as stroke, myocardial infarction and peripheral arterial embolism. Therefore a possible concern for women with malignancies undergoing ovarian stimulation for fertility preservation is the increased risk of venous or arterial thrombosis. METH...

The metalloproteinase ADAMTS13 (a disintegrin with a thrombospondin type 1 motif, member 13), also known as VWF (von Willebrand factor) protease, may be assessed in vast array of clinical conditions. Notably, severe deficiency characterizes TTP (thrombotic thrombocytopenic purpura), rare but potentially fatal disorder associated thrombosis due to accumulation prothrombotic ultra-large multimers...

INTRODUCTION Thrombotic thrombocytopenic purpura is a type of occlusive thrombotic microangiopathy that is not specific to pregnancy but occurs with an increased frequency during it. Prognosis of thrombotic thrombocytopenic purpura greatly depends on early diagnosis and treatment. As delivery does not generally cause resolution of thrombotic thrombocytopenic purpura, pregnancy termination is no...

Aim. To evaluate the role of polymorphic variants blood coagulation genes (F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1) in development myocardial infarction patients with malignant tumors thoracoabdominal localization.
 Materials and methods. The study included 143 operated oncological Department surgical methods treatment No.11 (thoracic Oncology) Blokhin National Medical Research Center On...

objective: thrombotic thrombocytopenic purpura (ttp) is the most malignant variant of microangiopathy that usually presents by typical symptoms including thrombocytopenia, hemolytic anemia, neurological abnormalities, fever and renal impairment. report of the case: we report a 12-year-old male presented by cytopenia, fever, purpura on his extremities, seizure and lethargy. peripheral blood smea...