Cushing's syndrome is a rare disease that results from prolonged exposure to supraphysiological levels of glucocorticoids. Severe and rapidly progressive cases are often, but not exclusively, attributable to ectopic ACTH secretion. Extreme hypercortisolism usually has florid metabolic consequences and is associated with an increased infectious and thrombotic risk. The authors report on a case o...

conclusions we observed acceptable results regarding both efficacy and safety with 62.5 mg of bosentan, twice daily in this group of patients. further clinical trials investigating pah with lower dosages of bosentan may be warranted. results no adverse drug reaction was observed during the follow-up. clinical worsening occurred in six (14%) patients, at least one year after treatment, two of th...

For two years, the entire world has been grappling with new challenge that is Covid-19 pandemic. In December 2019 in China’s largest province, Wuhan, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), was detected a patient severe respiratory failure. Shortly after, infections were all regions of world. So far, 265 million have confirmed around world, and 5.2 those infected died due ...

The clinical management of pulmonary embolism and deep venous thrombosis of the legs are similar and requires prolonged anticoagulation therapy. The standard diagnostic approach in patients suspected of pulmonary embolism is ventilation-perfusion (V/Q) lung scan and compression ultrasonography to detect deep venous thrombosis. This retrospective study analyzed the role of V/Q lung scan an...

OBJECTIVES The aim of the present study was to evaluate whether elevated D-dimer levels can predict subsequent thromboembolic and cardiovascular events in patients with atrial fibrillation during oral anticoagulant therapy. BACKGROUND Atrial fibrillation is associated with hemostatic abnormalities even during oral anticoagulant therapy. D-dimer levels reflect a pro-thrombogenic state and thus...

May-Thurner Syndrome, left iliac vein compression by the right artery, is a congenital permissive lesion that requires an additional insult prior to onset of symptoms. We present case 31-year-old gravida 1 para 0 at 28.6 weeks who presented emergency room with 2-month history progressive lower leg swelling since 21.2 weeks’ gestation. The patient endorsed incidence domestic violence 17 had twin...

OBJECTIVES To measure the D-dimer concentrations in both healthy dogs and dogs with and without evidence of thromboembolic disease/disseminated intravascular coagulation using a "Point-of-Care" test. METHODS Sixty-seven clinical cases and 26 healthy dogs were included in this retrospective study. D-dimer was measured using the NycoCard D-dimer test. Clinical conditions were categorised based ...