Chemical modifications of innate DNA/RNA aptamers facilitate the improvement their function. Herein, we report our modular strategy to manipulate a thrombin-binding DNA aptamer (TBA) improve its anticoagulation activity and binding affinity. A set amino acid conjugates, termed acid–nucleic hybrids or ANHs, was synthesized incorporated into TBA loop sequences. We found that substitutions with hy...

The current study was carried out to evaluate the shelf life of peeled shrimp during ice storage for 14 days using 125 µg/ml crude isoflavones extract (CIE), 250 moringa (CME) and a mixture both (62µg/ml CIE 25µg/ml CME), as an antioxidant antimicrobial agent. results showed that CME and/or in improved quality storage. All treated samples showed; low content total volatile nitrogen (TVN), trime...

Background/Aim: Drug-induced liver injury is one of the major causes acute failure. Under current circumstances pandemic COVID-19, use paracetamol which has a proven hepatotoxic effect increased. This prompts search for novel agents with hepatoprotective properties. The purpose this article was to evaluate activity cryoextract placenta (CEP) on model paracetamol-induced hepatitis. Methods: stud...

(ABSTRACTOxygen free radical mediated tissue injury is implicated as a major factor in the pathogenesis of the long term complications seen in the premature infant, and direct evidence of their role in the development of these long term problems is lacking. A prospective observational study of 78% of very low birthweight infants admitted to a level III neonatal intensive care unit in 1992 was u...

background: freezing is a common way and one of the best methods of seafood preservation for long periods of time; however, the freeze thawing process may influence the quality of food. objectives: oxidation and denaturation of proteins, sublimation and recrystallization of ice crystals can cause changes in the quality of the frozen products. this study was aimed to evaluate the effect of three...

a 42-d study was conducted to evaluate the influence of full-fat flaxseed (fs) and canola seed (cs) on broiler performance, fatty acid (fa) profile of meat, and the oxidative stability of meat during frozen storage. a total of 324 one-day old broiler chicks were randomly attributed to 6 experimental groups and fed iso-energetic and isonitrogenous diets as follows, c: control (soybean-corn); cs1...

abstract in this study, big-head carp flesh was processed and fish finger was produced by the formula of 1, 2 and 3 with 70, 80 and 93.5 percent of big head fish flesh respectively. then sensory attributes, biochemical changes and nutritional value such as peroxide value (pv), thiobarbituric acid (tba) and the total volatile nitrogen (tvb-n) changes and microbial load of all three formulas were...

The fact that oxidation, as one of the main routes of phase I metabolism of drugs, follows by conjugation reactions, and also formation of nitrenium ion as one of the clozapine oxidation products, directed us to investigate the oxidation of clozapine (CLZ) in the presence of nucleophile. The oxidation of clozapine (CLZ) has been studied on a glassy carbon electrode in the absence and presence o...