RidA (for Reactive Intermediate Deaminase A) proteins are ubiquitous, yet their function in eukaryotes is unclear. It is known that deleting Salmonella enterica ridA causes Ser sensitivity and that S. enterica RidA and its homologs from other organisms hydrolyze the enamine/imine intermediates that Thr dehydratase forms from Ser or Thr. In S. enterica, the Ser-derived enamine/imine inactivates ...

The metabolism of diclofenac has been reported to produce reactive benzoquinone imine intermediates. We describe the identification of mercapturic acid derivatives of diclofenac in rats and humans. Three male Sprague-Dawley rats were administered diclofenac in aqueous solution (pH 7) at 50 mg/kg by intraperitoneal injection, and urine was collected for 24 h. Human urine specimens were obtained,...

Hydroacylation reactions and aza-benzoin reactions have attracted considerable attention from experimental chemists. Recently, Wang et al. reported an interesting reaction of N-heterocyclic carbene (NHC)-catalyzed addition of aldehyde to enamide, in which both hydroacylation and aza-benzoin reactions may be involved. Thus, understanding the competing relationship between them is of great intere...

In the title compound, [Ti2(C16H14N2O2)2O2]·2CHCl3, the Ti(IV) atom in the centrosymmetric complex has a distorted octa-hedral N2O4 coordination environment and is linked via two μ2-oxido bridges into a dinuclear centrosymmetric com-plex, with a Ti⋯Ti separation of 2.7794 (8) Å. In the salen (N,N'-ethyl-enebis(salicyl-imine)) ligand, the two salicyl-imine units make a dihedral angle of 45.31 (5...

Describing kinetic processes within a perturbation theory approach such as Fermi's golden rule requires an understanding of the initial and final states of the system. A number of different methods have been proposed for obtaining these diabatic-like states, but a robust criterion for evaluating their accuracy has not been established. Here, we approach the problem of determining the most appro...

Imine chemistry represents an important category of chemical reactions involved in the biosynthesis plant natural products, ranging from newly discovered mobile defense hormone N-hydroxy-pipecolic acid to red-to-yellow tyrosine-derived betalain pigments. Spontaneous imine formation have also served as basis for evolution numerous metabolic enzymes, such specialized Pictet-Spenglerases that prod...

A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

Imine dynamic hydrogels are synthesized via dual-imine bond crosslinking from O-carboxymethyl chitosan (CMCS) and a water soluble dynamer using ‘green’ approach. Three dynamers prepared through reaction of benzene-1,3,5-tricarbaldehyde di-amino Jeffamine with molar mass 500, 800 1900, respectively. Hydrogels, namely H500, H800 H1900 then obtained by mixing CMCS aqueous solutions. FT-IR confirms...