نتایج جستجو برای: thermoresponsive

تعداد نتایج: 1274  

Journal: :Acta biomaterialia 2010
S Purushotham R V Ramanujan

The synthesis, characterization and property evaluation of drug-loaded polymer-coated magnetic nanoparticles (MNPs) relevant to multimodal cancer therapy has been studied. The hyperthermia and controlled drug release characteristics of these particles was examined. Magnetite (Fe(3)O(4))-poly-n-(isopropylacrylamide) (PNIPAM) composite MNPs were synthesized in a core-shell morphology by dispersio...

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2009
A Makó G Csóka E Pásztor S Marton G Horvai I Klebovich

The aim of this study was the formulation and examination of a novel thermoresponsive and bioadhesive, in situ gelling drug delivery system, which can be used in the treatment of oesophageal pain and inflammation. A bioadhesive cellulose derivative (Metolose) 60SH) was used as a thermoresponsive material, because Metolose has thermal gelation properties at certain temperature. The thermal gelat...

Journal: :The journal of gene medicine 2011
Siobhan S McMahon Natalia Nikolskaya Siobhan Ní Choileáin Niamh Hennessy Timothy O'Brien Padraig M Strappe Alexander Gorelov Yury Rochev

BACKGROUND The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried out using the natural biopolymer thermoresponsive gel, chitosan/β-glycerol phosphate (β-GP) as a carrier. METHODS Three chitosan/β-GP scaffolds were prepared with varying c...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2012
Conn L Hastings Helena M Kelly Mary J Murphy Frank P Barry Fergal J O'Brien Garry P Duffy

Critical limb ischaemia (CLI) is a debilitating ischaemic disease caused by vascular occlusion. Pro-angiogenic therapeutics have the potential to produce collateral vasculature, delaying or negating the need for amputation or invasive revascularisation. Thermoresponsive hydrogels can provide an in situ depot for the sustained release of drugs and provide protection and cohesion for encapsulated...

2015
Salla Välimäki Joona Mikkilä Ville Liljeström Henna Rosilo Ari Ora Mauri A. Kostiainen Max von Delius

Synthetic macromolecules that can bind and co-assemble with proteins are important for the future development of biohybrid materials. Active systems are further required to create materials that can respond and change their behavior in response to external stimuli. Here we report that stimuli-responsive linear-branched diblock copolymers consisting of a cationic multivalent dendron with a linea...

Journal: :Soft matter 2013
Matthew J Glassman Bradley D Olsen

A strategy for responsively toughening an injectable protein hydrogel has been implemented by incorporating an associative protein as the midblock in triblock copolymers with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) endblocks, producing materials with a low yield stress necessary for injectability and durability required for load-bearing applications post-injection. Responsive rein...

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