Over the years several studies have demonstrated the ability to identify potential drug-drug interactions via data mining from the literature (MEDLINE), electronic health records, public databases (Drugbank), etc. While each one of these approaches is properly statistically validated, they do not take into consideration the overlap between them as one of their decision making variables. In this...

Interaction is a familiar term to most biostatisticians. When the effect of one factor differs across levels of a second factor, interaction between the factors is present. Drug disposition refers to the processes of how a drug is absorbed, distributed, metabolized (broken down), and excreted [6]. Variations in drug disposition and/or effect may result from interactions with, for example, disea...

In this review we examine computational approaches to explore the structure and thermodynamics of water binding in protein–drug complexes

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...

INTRODUCTION A drug interaction is a pharmacological response which cannot be explained by the action of a single drug but may be due to two or more drugs acting simultaneously but The effects of a drug may also be changed by the presence of food, drink or by some environmental chemical agent. The outcome of a drug interaction may be harmful if the interaction results in increased efficacy or t...