The transient dimerization of transmembrane proteins is an important event in several cellular processes and computational methods are being increasingly used to quantify their underlying energetics. Here, we probe the thermodynamics and kinetics of a simple transmembrane dimer to understand membrane protein association. A multi-step framework has been developed in which the dimerization profil...

The quantitative analysis of biochemical reactions and metabolites is at frontier of biological sciences. The recent availability of high-throughput technology data sets in biology has paved the way for new modelling approaches at various levels of complexity including the metabolome of a cell or an organism. Understanding the metabolism of a single cell and multi-cell organism will provide the...

Spent bleaching clay from the oil refining industry was subjected to heat regeneration in a box furnace with air. The heat reactivation was conducted without previous extraction of residual oil and with previous extraction of oil using organic solvent. The experimental temperature ranged from 723 at 873 K. A model for the kinetic of thermal reactivation of spent adsorbent has been proposed. The...

Geological carbon sequestration captures CO2 from industrial sources and stores the CO2 in subsurface reservoirs, a viable strategy for mitigating global climate change. In assessing the environmental impact of the strategy, a key question is how microbial reactions respond to the elevated CO2 concentration. This study uses biogeochemical modeling to explore the influence of CO2 on the thermody...

REINHART HEINRICH, §, FRANCISCO MONTERO, ¶, EDDA KLIPP, §, THOMAS G. WADDELL,~ and ENRIQUE MELI~NDEZ-HEVIAt § Humboldt-Universitat zu Berlin, Institut for Biologie, Theoretische Biophysik, D-I 0115 Berlin, Germany ¶ Universidad Complutense de Madrid, Departamento de Bioquimica, 28040 Madrid, Spain ~:University of Tennessee, Department of Chemistry, Chattanooga, TN, USA. tUmversidad de la Laguna...

Several serotonin reuptake inhibitors are in clinical use for treatment of depression and anxiety disorders. However, to date, reported pharmacological differentiation of these ligands has focused mainly on their equilibrium binding affinities for the serotonin transporter. This study takes a new look at antidepressant binding modes using radioligand binding assays with [(3)H]S-citalopram to de...

Heteroepitaxial growth of highly strained structures offers the possibility to fabricate islands with very narrow size distribution, coined self-assembling quantum dots (SAQD). In spite of the high experimental interest, the mechanism of SAQD formation is not well understood. We will show that equilibrium theories can successfully predict the island sizes and densities, the nature and the magni...

The principles that govern the emergence of life from non-life remain a subject of intense debate. The evolutionary paradigm built up over the last 50 years, that argues that the evolutionary driving force is the Second Law of Thermodynamics, continues to be promoted by some, while severely criticized by others. If the thermodynamic drive toward ever-increasing entropy is not what drives the ev...

The objective of this work is investigation of the adsorption and decomposition of Reactive Blue 19 from industrial wastewaters using laccase enzyme immobilized on activated carbon powder and fiber as adsorbent. Time, pH, temperature, stirring rate, the amount of the adsorbent, dye initial concentration, solution flow rate in the column and column height were studied as key operating parame...