Developmentally regulated V(D)J recombination profoundly influences immune repertoires, but the underlying mechanisms are poorly understood. In the endogenous T cell receptor Cgamma1 cluster, the 3' Vgamma3 gene (closest to Jgamma1) rearranges preferentially in the fetal period whereas rearrangement of the 5' Vgamma2 gene predominates in the adult. Reversing the positions of the Vgamma2 and Vga...

Electronic charge rearrangement between components of a heterostructure is the fundamental principle to reach electronic ground state. It acknowledged that density state distribution governs amount transfer, but notable dependence on temperature not yet considered, particularly for weakly interacting systems. Here, it experimentally observed ground-state transfer in van der Waals formed by mono...

Indoor Environmental Quality (IEQ) is a very important aspect in the design of spaces. It depends on fundamental requirements, and it aims to improve living quality ensure high well-being for occupants. Poor IEQ has significant health consequences as people spend considerable portion their time indoors. The restrictions imposed by current SARS-CoV-2 pandemic have worsened this situation requiri...

OBJECTIVE To evaluate the usefulness of morphologic diagnosis, immunophenotyping and immunoglobulin (Ig) and T-cell receptor (TcR) gene rearrangement studies in the diagnosis of lymphoproliferative disorder. DESIGN A retrospective cohort study with clinical follow-up of controversial cases. SETTING Single institution, tertiary care centre. PATIENTS All 273 patients whose lymphoid tissue s...

Rearrangement reactions are a very powerful tool for the conversion of simple substrates into highly functionalized products in organic chemistry. In combination with an attractive initiation process, such as visible-light catalysis, these particularly powerful. Read more about recent progress on aryl migration reactions, focusing especially Smiles rearrangement and related Review by E. Brachet...