نتایج جستجو برای: therapeutic substitution
تعداد نتایج: 407128 فیلتر نتایج به سال:
Journal:
:The Canadian Journal of Hospital Pharmacy
2012
Journal:
:Blood
2012
Alessio Cantore
Nisha Nair
Patrizia Della Valle
Mario Di Matteo
Janka Màtrai
Francesca Sanvito
Chiara Brombin
Clelia Di Serio
Armando D'Angelo
Marinee Chuah
Luigi Naldini
Thierry Vandendriessche
Gene therapy may provide a cure for hemophilia and overcome the limitations of protein replacement therapy. Increasing the potency of gene transfer vectors may allow improvement of their therapeutic index, as lower doses can be administered to achieve therapeutic benefit, reducing toxicity of in vivo administration. Here we generated codon-usage optimized and hyperfunctional factor IX (FIX) tra...
Journal:
:Proceedings of the London Mathematical Society
2021
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