Abstract Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges the brain predisposition to generate epileptic seizures resulting in broad spectrum neurobiological insults, imposing psychological, cognitive, social also economic burdens sufferer. Voltage-gated sodium channels (VGSCs) are essential for generation propagation action pot...

Thromboembolic disease is a common cause of morbidity and mortality. Thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. Anticoagulation is a major intervention for the management of arterial and venous thromboembolic events. Dabi...

Diastolic phase of cardiac function is associated with lower arterial flow and hence higher concentration of intra arterially injected drug is achieved at the site of injection. It is herein postulated that drugs show higher efficacy when injected during the diastolic phase of cardiac function. It is also postulated that this benefit cannot be achieved when the drug is injected with higher rate...