Background Healthy people with a family history of alcohol problems show a pattern of subjective responses to alcohol that resemble those of affected probands. Studies on ketamine suggest that up-regulation of N-methyl-D-aspartate receptors (NMDARs) underlies these effects, and point to a pharmacologically-responsive endophenotype reflecting enhanced risk for alcohol-use disorders. Methods Su...

Organisms are expected to be sensitive to cues of genetic relatedness when making decisions about social behaviour. Relatedness can be assessed in several ways, one of which is phenotype matching: the assessment of similarity between others' traits and either one's own traits or those of known relatives. One candidate cue of relatedness in humans is facial resemblance. Here, I report the effect...

pervasive mobile computing, consumer experience, participatory design The belief motivating the 4D Experience research programme is that the experience evoked by a computer system can be (at least) as important as the ostensible functionality of the system. In this report, we describe three case studies that explore the experiential approach to system development: Zap Scan, A Walk in the Wired ...

We reassess the "dispersionless transport regime" of Brownian particles in tilted periodic potentials. show that exhibit normal diffusive motion right after transitioning into running state dragged by constant bias force. No special transient dynamics appears, contrary to conjectures previous studies. The observed flat segment dispersion evolution curve is solely due broad spatial distribution ...

Knowledge of physical conditions in molecular clouds is a prerequisite for deriving the distribution of molecular material in the Milky Way and other galaxies, understanding star formation within these dense regions, the stellar initial mass function, and appreciating the eeects of interaction of young stars with their natal environment. In this lecture, I review some of the basic techniques fo...

As a key factor to enable interoperability in the Semantic Web (Berners-Lee, Hendler & Lassila, 2001), ontologies are developed by different organisations at a large scale, also in overlapping areas. Therefore, ontology mapping has come into forth to achieve knowledge sharing and semantic integration in an environment where knowledge and information are represented by different underlying ontol...