hyper ige syndrome (hies) is a rare primary immunodeficiency disease. most of hies cases are sporadic. hies type ad is caused by mutation in signal transducer and activator of transcription-3 (stat-3). a number of mosaicism hies has been reported that is associated with intermediate phenotype. autosomal recessive hies (ar-hies) is due to mutation in dock-8 or cytokine sis 8 and tyk2 or tyrosine...

background: asthma is a multifactorial disease and its severity varies with the inflammatory grade. there are conflicting reports about the roles of trace elements in asthma. this study examined the effects of zinc (zn), copper (cu), and selenium (se) concentrations in sera of patients with allergic asthma attending ghaem hospital, mashhad, iran. methods: forty-nine patients, aged 10 to 50 year...

hyper-igm syndromes are characterized by profound reduction of serum igg, iga, and ige levels with normal or increased concentrations of serum igm. cd40 ligand deficiency is x-linked form of the disease, which results in a lack of immunoglobulin class switching from igm to igg in b cells. in addition to the recurrent infections, a number of patients suffer from neutropenia. there are some evide...

in this study the land surface in western half of hyper-arid lut desert, in south east of iran, which is covered by yardangs, a worldwide typical landform for aeolian erosion, were classified by self organizing maps (som) method. in the first step by using digital elevation model with 10 m resolution and matlab software, 22 morphometric parameters were calculated based on derivative of the surf...

A topological index is a function having set of graphs as its domain and real numbers range. Here we concentrated on indices involving the number vertices, edges maximum minimum vertex degree. The aim this paper to compute lower upper bounds second Zagreb index, third Hyper Harmonic Redefined first First reformulated Forgotten square F-index, Sum-connectivity Randic Reciprocal Gourava Sombar Ni...

Hyperbolicity measures, in terms of (distance) metrics, how close a given graph is to being a tree. Due to its relevance in modeling real-world networks, hyperbolicity has seen intensive research over the last years. Unfortunately, the best known algorithms for computing the hyperbolicity number of a graph (the smaller, the more tree-like) have running time O(n), where n is the number of graph ...