Background: In light of the latest global financial crisis and the ongoing sovereign debt crisis, accurate measuring of market losses has become a very current issue. One of the most popular risk measures is Value-at-Risk (VaR). Objectives: Our paper has two main purposes. The first is to test the relative performance of selected GARCH-type models in terms of their ability of delivering volatil...

The genetic polymorphism affecting the CYP3A5 enzyme is responsible for inter-individual and interethnic variability in the metabolism of CYP3A5 substrates. The aim of this study was to analyze the distribution of the most common CYP3A5*3 allelic variants in the healthy population of R. Macedonia and to investigate if the allelic frequency falls within the assumed range for European Caucasians....

One of the most noble professions of all the times is teaching. The rapid expansion of computer technology brought many changes in all areas of our lives, as well as in the teaching process. Actually, today every child uses the computer for fun and entertainment, so why not for learning his lessons too. The Interactive multimedia learning systems connect classroom curricula with real world situ...

In the paper alternatives for expansion of Macedonian electricity supply system are presented. MESSAGE tool is used modelling system, developing scenarios, to analyse cost optimal energy pathways and determine generation technology mix. The calculations period 2020-2050 made in a 5-year interval. Two scenarios developed: Scenario 1 – BAU (Business as Usual) scenario, where current structure pre...

Introduction:B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with many patients surviving for decades with watch and wait strategy or no treatment, whereas others surrender to their disease despite therapy. In recent years, new molecular prognostic factors came to light that have significantly improved the stratification of the CLL patients. One of the most impor...

OBJECTIVES Despite a 92-99% national vaccination coverage since 2000, the former Yugoslav Republic of Macedonia experienced a large measles outbreak between 2010 and 2011. Here we investigate the characteristics of patients hospitalized during this outbreak at the Clinic of Infectious Diseases in Skopje. METHODS Epidemiological, clinical and laboratory data of 284 measles patients, including ...