Objective: Thalassemic patients are at risk of zinc deficiency due to various causes including desferal injection, hyperzincuria, high ferritin levels, and hepatic iron overload. We evaluate the effect of zinc supplementation on linear growth of beta-thalassemia patients. Methods: one-hundred beta-thalassemic major patients whose heights were within 3rd to l0th percentile were randomly divided ...

background: thalassemic patients undergoing hematopoietic stem cell transplantation (hsct) are faced with cumulative high level of oxidative stress and depletion of critical antioxidants. administration of antioxidants, is promising towards minimizing oxidative damage in both thalassemic and hsct patients. method: this was a prospective cross-sectional observational study. patients as a part of...

β- thalassemia major is a common hemoglobinopathy in humans. in some journals, numerous studies have reported different prevalence of hepatitis c among β- thalassemia major because thalassemic patients need multiple blood transfusions and blood transfusion is a common transmission pathway for hepatitis c virus. thus this study was performed for detection of anti-hcv between β- thalassemia major...

introduction: in 1989, the first successful umbilical cord blood transplantations (ucbts) was reported in a boy with fanconi's anemia, using umbilical cord (ucb) of his hla matched sister. cord blood transplantation is a good substitute for bone marrow or peripheral blood transplantation especially for children and small body size adults. methods: between 1998 and 2007 ,14 children(10 boys and ...

Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, the...

OBJECTIVE Recently published animal studies indicate that leptin and ghrelin play a role in puberty initiation and progress as well as in reproduction. The aim of our study was to evaluate the relation of these two hormones to the pubertal maturity and fertility status in patients with beta-thalassemia. DESIGN Blood levels of leptin, acylated ghrelin and sex hormones were determined in 97 (59...

Chronic diseases have been identified as predisposing factors in behavioral disorders and the prevalence of these disorders is known to be higher in patients than in control groups. Thalassemia too, plays an effective role in increasing the prevalence of behavioral disorders. In order to recognize the prevalence of behavioral disorders in thalassemic patients, a study was performed on 257 ...

Hemoglobinopathies have a protective role in malaria that appears to be related to alterations in red blood cell (RBC) properties. Thalassemic RBCs infected with Plasmodium falciparum showed greatly reduced cytoadherence and rosetting properties as well as impaired growth and multiplication. A significant decrease in the levels of falciparum antigens associated with the membrane of infected bet...