The β-thalassemias are a group of hereditary hematological diseases caused by over 300 mutations of the adult β-globin gene. Together with sickle cell anemia, thalassemia syndromes are among the most impactful diseases in developing countries, in which the lack of genetic counseling and prenatal diagnosis have contributed to the maintenance of a very high frequency of these genetic diseases in ...

textbook of the European Association of Echocardiography and is jointly sponsored by the European Society of Cardiology. Th e editors were able to attract a team of 50 expert cardiologist echocardiographists. In 488 pages, this text book covers most aspects of echocardiography, from the basics to innovative imaging techniques. Th e fi rst chapters cover ultrasound imaging principles and trans t...

Thalassemia is an inherited blood disorder imposing a significant social and economic burden. Comprehensive screening strategies are essential for the prevention management of this disease. Third-generation sequencing (TGS), breakthrough technology, has shown great potential diagnostic applications in various diseases, while its application thalassemia detection still infancy. This review aims ...

Early fetal echocardiography (EFEC) is a fetal cardiac ultrasound analysis performed between the 12th and 16th week of pregnancy (compared with the usual 18-22 weeks). In the last 10 years, the introduction of “aneuploidy sonographic markers” in screening for cardiac defects has led to a shift from late second to end of the first trimester or beginning of the second trimester of pregnancy for s...

Trans-thoracic echocardiography (TTE) is an important non-invasive cardiac examination that provides structural and functional information. It is useful in the diagnosis of cardiac diseases and often guides the management and follow-up of patients with cardiovascular diseases (CVD). The study aimed to present an audit of the echocardiograms performed in an urban private hospital over a two-year...

stem cells are undifferentiated cells with the ability of proliferation, regeneration, conversion to differentiated cells and producing various tissues. stem cells are divided into two categories of embryonic and adult. in another categorization stem cells are divided to totipotent, multipotent and unipotent cells. so far usage of stem cells in treatment of various blood diseases has been studi...

What is the problem and what is known about it? Cardiovascular diseases (CVD) involve the heart or blood vessels. More than 17 million people died from CVD in 2008 and each year, heart disease kills more Americans than cancer. Cardiovascular disease remains the biggest cause of deaths in the world. However, during the last 20 years, CVDs have declined in many rich countries but have increased a...

Resting measurement of only left ventricular systolic function, is not enough sufficient parameter that predicts exercise capacity in patients with cardiac disease. Therefore, left ventricular filling shortly after an acute myocardial infarction (AMI) was prospectively studied to determine whether it could predict subsequent exercise time. Consecutive AMI patients underwent Doppler and two-dime...