CS5931 is a novel anticancer agent isolated from the sea squirt Ciona savignyi. However, its content in the species is very low, and developing a novel approach for production of the polypeptide is promising. In the present study, we expressed and purified the polypeptide from E. coli, and the fermentation conditions were studied using response surface methodology. The yield of CS5931 was incre...

BACKGROUND Metabolic syndrome is a cluster of metabolic risk factors including dyslipidemia, impaired glucose tolerance, hypertension and central obesity. BDNF (Brain-derived neurotrophic factor) and leptin have been implied in the energy homeostasis. The purposes of this study were to examine concentrations of leptin, BDNF and biochemical parameters in metabolic-syndrome subjects and healthy c...

Melioidosis, infection caused by the Gram-negative bacterium Burkholderia pseudomallei, is a common cause of sepsis in northeast Thailand. In white North Americans, common functional genetic variation in TLR1 is associated with organ failure and death from sepsis. We hypothesized that TLR1 variants would be associated with outcomes in Thais with melioidosis. We collated the global frequencies o...

Nasopharyngeal carcinoma (NPC) is a serious health problem in Thailand. It is caused by the combined effects of Epstein-Barr virus (EBV), carcinogens and genetic susceptibility. The glutathione S-transferase M1 gene (GSTM1) encodes a phase II enzyme responsible for detoxifying carcinogenic electrophiles. Polymorphic null forms of the gene GSTM1 lack enzyme activity and have been associated with...

Melioidosis is a communicable disease caused by the gram-negative bacterium Burkholderia pseudomallei, usually found in soil, water, and mammals. This highly prevalent Southeast Asia Northern Australia. The transmission spreads through percutaneous inoculation, inhalation, or ingestion, which challenging to diagnose treat. Therefore, researcher’s findings on prevalence of incidence 2019 one pro...

O objetivo do presente trabalho foi propor uma meta-análise da avaliação realizada pelos pesquisadores Thais Waideman Niquito e Adolfo Sachsida, então no Instituto de Pesquisa Econômica Aplicada (IPEA), em 2018. Esses autores concluíram, com base nos dados Exame Nacional Ensino Médio - ENEM, que a Filosofia Sociologia obrigatórias impactou negativamente os rendimentos dos discentes nas outras á...

BACKGROUND Human neutrophil antigens (HNAs) are involved in autoimmune and alloimmune neutropenia and transfusion-related acute lung injury. The HNA-1 system is important in immunogenetics, and allele frequencies have been described in different populations. This study investigated the frequency of FCGR3B alleles encoding HNA-1a, HNA-1b, and HNA-1c among Thai blood donors and compared these fre...