Nephron function is stabilized by tubuloglomerular feedback (TGF). TGF operates within the juxtaglomerular apparatus, sensing changes in tubular flow and eliciting compensatory changes in single nephron GFR (SNGFR). The mediator(s) of TGF remains unconfirmed. One theory is that ATP consumed in active transport by the macula densa leads to formation of adenosine, which causes glomerular vasocons...

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Self-assembling peptide hydrogels were modified to deliver transforming growth factor b1 (TGF-b1) to encapsulated b...

Abstract Background and Aims The peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been shown to dampen TGF-β signaling suppress miR-130a in VSMCs also profibrotic miR-21-5p the kidney. We recently demonstrated that pioglitazone ameliorates established renal fibrosis by suppressing STAT3 EGR1 [1], but its effect on has not investigated. Thus, we aimed study how chronic oral tre...

Systemic sclerosis (SSc) is a connective tissue disorder representing fibrosis in the skin and internal organs such as lungs. An activated differentiation of local progenitor cells to myofibroblasts likely key mechanism underlying overproduction extracellular matrix resultant SSc. Calpains are family members Ca2+-dependent cysteine proteases for which biological action may contribute various or...

Background/Aim. The studies of hydroxyapatite (HAp) and growth factors as the materials used for direct pulp capping have produced conflicting results both issue inflammatory response calcified bridge formation. Hap/poly (lactide-co-glycolide) (HAp/PLGA) is a bioresorbable polymer with demonstrated good characteristics carrier bone morphogenetic protein necessary in tissue regeneration. role de...

Fine particulate matter (PM2.5) is an important component of air pollution and can induce lung inflammation oxidative stress. We hypothesized that PM2.5 could play a role in the induction pulmonary fibrosis. examined whether multiple intranasal instillation fibrosis mouse, also investigated underlying pro-fibrotic signaling pathways. C57/BL6 mice were intranasally instilled with 50 ?l suspensio...

Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGF? due mutations in the receptors and/or downstream signaling molecules. influences CRC only indirectly via stromal cells, such as cancer-associated fibroblasts. However, cell ability directly respond currently remains unexplored. This represents a missed opportunity for diagnostic and therapeutic interventions. Method...

Abstract The skin is outermost barrier in the body. Its only breaches are represented by hair follicles, which represent point of entrance for all skin-sitting pathogens and commensals. Therefore, they can be defined as most immunologically active sites skin. As such, tight regulation needed at these it achieved not through immune cells, but also non-hematopoietic cells like keratinocytes fibro...

Although TGF-β is known to be related tumor proliferation, invasion and epithelial-mesenchymal transition (EMT), its effects on oral carcinomas remain unclear. This study aimed elucidate the of squamous cell carcinoma (OSCC). In present in vitro study, three human OSCC lines; SAS (tongue cancer), Ca9-22 (mandibular gingival cancer) HSC-3 (cervical lymph nodes metastasis tongue were treated with...