نتایج جستجو برای: tgfβ

تعداد نتایج: 3626  

2010
Sarah MCLEAN Gianni M. DI GUGLIELMO

The TGFβ (transforming growth factor β) pathway is an essential cell signalling pathway that is implicated in both normal developmental processes, such as organogenesis, and pathological disorders, such as cancer and fibrosis. There are three prototypical TβRs (TGFβ receptors): TβRI (TβR type I), TGβRII (TβR type II) and TGFβRIII (TβR type III, also known as betaglycan). Whereas the role of TβR...

2014
Marilyn M. Dysart Boris R. Galvis Armistead G. Russell Thomas H. Barker Adam J. Engler

Dysfunctional pulmonary homeostasis and repair, including diseases such as pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), and tumorigenesis have been increasing over the past decade, a fact that heavily implicates environmental influences. Several investigations have suggested that in response to increased transforming growth factor--beta (TGFβ) signaling, the alveolar t...

Journal: :Cancer prevention research 2014
Amber A Bokhari Laura R Lee Dewayne Raboteau Chad A Hamilton George L Maxwell Gustavo C Rodriguez Viqar Syed

Increased expression of TGFβ isoforms in human endometrial cancer correlates with decreased survival and poor prognosis. Progesterone has been shown to exert a chemoprotective effect against endometrial cancer, and previous animal models have suggested that these effects are accompanied by changes in TGFβ. The goal of this study was to characterize the effect of progesterone on TGFβ signaling p...

Journal: :Journal of the National Cancer Institute 2016
V L Martins M P Caley K Moore Z Szentpetery S T Marsh D F Murrell M H Kim M Avari J A McGrath R Cerio A Kivisaari V M Kähäri K Hodivala-Dilke C H Brennan M Chen J F Marshall E A O'Toole

BACKGROUND Individuals with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop unexplained aggressive squamous cell carcinomas (SCC). Here we report that loss of type VII collagen (Col7) in SCC results in increased TGFβ signaling and angiogenesis in vitro and in vivo. METHODS Stable knockdown (...

2011
Giuseppe Pirozzi Virginia Tirino Rosa Camerlingo Renato Franco Aantonello La Rocca Eleonora Liguori Nicola Martucci Francesca Paino Nicola Normanno Gaetano Rocco

BACKGROUND Cancer Stem Cells (CSCs) hypothesis asserts that only a small subset of cells within a tumour is capable of both tumour initiation and sustainment. The Epithelial-Mesenchymal Transition (EMT) is an embryonic developmental program that is often activated during cancer invasion and metastasis. The aim of this study is to shed light on the relationship between EMT and CSCs by using LC31...

2016
Lindsay C. Spender G. John Ferguson Sijia Liu Chao Cui Maria Romina Girotti Gary Sibbet Ellen B. Higgs Morven K. Shuttleworth Tom Hamilton Paul Lorigan Michael Weller David F. Vincent Owen J. Sansom Margaret Frame Peter ten Dijke Richard Marais Gareth J. Inman

Recent data implicate elevated transforming growth factor-β (TGFβ) signalling in BRAF inhibitor drug-resistance mechanisms, but the potential for targeting TGFβ signalling in cases of advanced melanoma has not been investigated. We show that mutant BRAFV600E confers an intrinsic dependence on TGFβ/TGFβ receptor 1 (TGFBR1) signalling for clonogenicity of murine melanocytes. Pharmacological inhib...

2015
Fabienne Brenet Joseph M Scandura

Hematopoietic stressors such as infection, bleeding, or toxic injury trigger a hematopoietic adaptation that sacrifices hematopoietic stem and progenitor cell (HSPC) quiescence to meet an urgent need for new blood cell production. Once the hematopoietic demands are adequately met, homeostasis must be restored. Transforming growth factor β (TGFβ) signaling is a central mediator mandating the ret...

2014
Laura Rodón María del Mar Inda Elena Martínez-Sáez Joan Seoane

In advanced cancer, including glioblastoma, the TGFβ pathway acts as an oncogenic factor. Some tumors exhibit aberrantly high TGFβ activity, and the mechanisms underlying this phenomenon are not well understood. We have observed that TGFβ can induce TGFβ2, generating an autocrine loop leading to aberrantly high levels of TGFβ2. We identifi ed cAMP-responsive element–binding protein 1 (CREB1) as...

2011
Eric S Sobel Todd M Brusko Ed J Butfiloski Wei Hou Shiwu Li Carla M Cuda Ariana N Abid Westley H Reeves Laurence Morel

INTRODUCTION CD25(+) FOXP3(+) CD4(+) regulatory T cells (Tregs) are induced by transforming growth factor β (TGFβ) and further expanded by retinoic acid (RA). We have previously shown that this process was defective in T cells from lupus-prone mice expressing the novel isoform of the Pbx1 gene, Pbx1-d. This study tested the hypothesis that CD4(+) T cells from systemic lupus erythematosus (SLE) ...

Journal: :Journal of molecular cell biology 2013
Thomas Gruber Reinhard Hinterleitner Natascha Hermann-Kleiter Marlies Meisel Ingo Kleiter Chiuhui Mary Wang Antonella Viola Christa Pfeifhofer-Obermair Gottfried Baier

T cell-intrinsic transforming growth factor β (TGFβ) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate the sensitivity of T cells to TGFβ; however, the mechanism underlying this process is unknown. This study shows that SMAD7, an established negative regulator of TGFβ receptor (TGFβR) signaling, is a key downstrea...

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