A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.

Introduction Nigeria remains among the few countries that are yet to achieve eradication of neonatal tetanus in the world despite the availability of an effective vaccine. This study investigated immunity against tetanus in primiparous mothers and neonates at birth, and identified associated factors. Methods This cross-sectional study involved consecutive selection of 244 primiparous mother-n...

OBJECTIVE To determine the persistence of antibody to diphtheria, tetanus, and pertussis in children receiving an accelerated schedule of primary immunisation. DESIGN Controlled study of antibody testing of blood samples from children immunised according to various schedules: three doses of triple vaccine completed at 8-13 calendar months, 6-7 calendar months, before 6 calendar months, or thr...

Fragment C of tetanus toxin appears to retain most of the determinants of the tetanus toxin molecule insofar as interactions with neural or thyroid membranes and with gangliosides are concerned. Thus, unlabeled fragment C is nearly as effective as unlabeled tetanus toxin in inhibiting the binding of either ‘251-labeled toxin or ‘251-labeled thyrotropin to neural or thyroid membranes. ‘251-label...

A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test). In this study, the serum titers (values between 1.0 and 19.5 IU) measured by a modified TOBI test (Modi-TOBI test) and toxin neutralization as...

The aged people belong to most vulnerable group for tetanus infection in terms of their vaccination history, frequency of injuries, which may serve as gate of entry for this infection and declared decrease of general as well as specific immunity. The examinations of the aged people for antitetanus antibodies have been done to assess the immunity against tetanus in this particular group of peopl...

Tetanus toxin was found to be a potent inhibitor of neurosecretion in the rat pheochromocytoma cell line PC12, a system in which biochemical and functional studies could be performed in parallel. Incubation of the cells with 10 nM tetanus toxin (3 h) led to an inhibition of acetylcholine release by 75-809’0 when evoked by 200 MM veratridine, 1 mM carbachol, or 2 mM Bas’. The main characteristi...

Tetanus, which can be eliminated through an effective immunization programme, remains a significant cause of morbidity and mortality in Uganda with a high case fatality rate. This study was carried out in St Francis Hospital Buluba (SFHB) after observing that the hospital was registering an abnormally high number of tetanus patients. Its aim was to retrospectively establish the socio-demographi...

Cephalic tetanus is an emergency condition, which is commonly observed in child age group here we report a case of 68-year-old man with the complain of right sided weakness for one day, associated with difficulty in breathing and speech, history of fall also present, case was diagnosed as cephalic tetanus. Here we report a case of cephalic tetanus in an elderly patient.