Over the last 15 years there has been growing recognition of the benefits of testosterone supplementation therapy (TST) for men with testosterone deficiency (TD), also termed hypogonadism. These benefits include improved sexual interest and performance, improved mood, energy, increased muscle and bone density, decreased fat, and possibly improved longevity. The new interest in TST has precipita...

The incidence of cardiovascular disease (CVD) is increased in the endocrine-metabolic condition polycystic ovary syndrome (PCOS) which impacts 10-15% females. mechanisms cardiac dysfunction PCOS related to hyperandrogenemia, and androgen receptor (AR) estrogen (ER) activation remain unclear. aim this study was investigate effect treatment on AR ER activation, fatty acid metabolism function a PC...

This study is aimed at investigating the effect of SHBG (rs727428; rs10822184) and LPL (rs754493647) single nucleotide polymorphisms on concentration bioavailable fraction testosterone in older men.
 Materials methods To gene mutations, 417 residents East Kazakhstan region Kazakh nationality were examined. The main group included 135 men with signs hypogonadism (AMS 37-49), control consist...

BACKGROUND Polycystic ovary syndrome (PCOS) patients typically have 17-hydroxyprogesterone (17OHP) hyperresponsiveness to GnRH agonist (GnRHa) (PCOS-T). The objective of this study was to determine the source of androgen excess in the one-third of PCOS patients who atypically lack this type of ovarian dysfunction (PCOS-A). METHODS Aged-matched PCOS-T (n= 40), PCOS-A (n= 20) and controls (n= 3...

1181. [28] Agarwal PK, Oefelein MG. Testosterone replacement therapy after primary treatment for prostate cancer. J Urol 2005;173: 533–6.[29] Kaufman JM, Graydon RJ. Androgen replacement after curative radical prostatectomy for prostate cancer in hypogonadal men. J Urol 2004;172:920–2.[30] Morgentaler A. Testosterone therapy in men with prostate cancer: scientific and ethical considerat...

introduction: the aim of the present study is to investigate the effect of interaperitoneal injection of baclofen (gaba-b agonist) and cgp35348 (gaba-b antagonist) on serum testosterone concentration in aggressive rats exposed to electromagnetic field. methods: fifty five mature male rats weighing 200±20 grams were studied. animals were divided into 2 main groups and four subgroups. main groups...

The purpose of this study was to compare the serum levels of androgens between hyposexual and non-hyposexual patients with epilepsy. Adult male patients with epilepsy were investigated. Serum levels of testosterone (T) and free-T, estradiol, and sex hormone binding globulin (SHBG) were measured and the free androgen index (FAI) was calculated. While there were no differences between hyposexual ...

the purpose of this study was to determine the effects of official soccer competition on saliva cortisol, testosterone and immunoglobulin a in male players. for this purpose, 14 fixed players (age: 28.24±4.3 years) were equally selected from two opponent teams in 2009 elimination cup. saliva samples at the rest and immediately after the first half time, before and after the second half time wer...

Testosterone deficiency (TD) afflicts approximately 30% of men aged 40-79 years, with an increase in prevalence strongly associated with aging and common medical conditions including obesity, diabetes, and hypertension. A strong relationship is noted between TD and metabolic syndrome, although the relationship is not certain to be causal. Repletion of testosterone (T) in T-deficient men with th...

Introduction: Correlation between circulating sex steroid levels and breast cancer has been controversial, with measurement of free, or bioavailable hormone rarely available. Salivary hormone levels represent the bioavailable fraction. We aimed to assess correlation between salivary sex steroid levels and breast cancer prevalence. Methods: Salivary hormone levels of testosterone (T), Estradiol ...