A novel variant of histone H2A, named as testis specific expressed gene 1 (TSEG-1, approved symbol: H2afb1), was identified from adult mouse testis. The TSEG-1 gene is 610-bp in length and consists of one exon. TSEG-1 transcript was robustly and exclusively expressed in adult mouse testis, mainly in spermatocytes. In developmental testis, the TSEG-1 transcript was robustly expressed since postn...

Nickel subsulfide (Ni:S ) was injected in various amounts into the testis of adult Fischer rats for the study of the acute and chronic effects of Ni S on testicular cells. Rats given injections of 0.6 to 10 mg of Ni;S developed an immediate inflammatory response at the site of injection, followed by a delayed, slowly evolving coagulation necrosis of seminiferous tubules and intersti tial cells....

The current study examines the expression and potential actions of neurotropin-3 (NT3), nerve growth factor (NGF), and their receptors during morphological sex determination (seminiferous cord formation) and perinatal rat testis development. The expression of neurotropins and their receptors was analyzed with immunohistochemistry. Cellular localization of neurotropin ligand and receptor protein...

In a recent article, Archambeault and Yao (1) reported that genetic disruption of activin A resulted in a failure of fetal testiscord elongation and expansion because of decreased Sertoli cell proliferation. They uncovered a role of fetal Leydig cells during testis-cord morphogenesis through activin A signaling pathway. As shown in the study, Sertoli cell proliferation was obviously higher in t...

The developing testis provides an environment that nurtures germ cell development, ultimately ensuring spermatogenesis and fertility. Impacts on this environment are considered to underlie aberrant germ cell development and formation of germ cell tumour precursors. The signaling events involved in testis formation and male fetal germ cell development remain largely unknown. Analysis of knockout...

Following chronic (15 or 30 days) treatment with oestradiol 3-benzoate (75 microg rat(-1) day(-1) in 100 microl of olive oil) to adult rats, androgen receptor (AR) expression was analysed simultaneously in testis, epididymis, seminal vesicle, prostate and pituitary utilising three independent tools i.e. immunohistochemistry, Western blotting and RT-PCR. All the five organs showed higher AR tran...

Embryonic testis development requires the morphogenesis of cords and growth of all cell populations to allow organ formation. It is anticipated that coordination of the growth and differentiation of various cell types involves locally produced growth factors. The current study was an investigation of the hypothesis that transforming growth factor-alpha (TGF-alpha) is involved in regulating embr...

BACKGROUND Surfactant proteins (SPs) have been described in various tissues and fluids including tissues of the nasolacrimal apparatus, airways and digestive tract. Human testis have a glandular function as a part of the reproductive and the endocrine system, but no data are available on SPs in human testis and prostate under healthy and pathologic conditions. OBJECTIVE The aim of the study w...

The testis is the primary organ involved in male germ cell production. It is under the control of the hypothalamus, which regulates the secretion of the pituitary gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH). The testis is composed of numerous thin, tightly coiled ducts known as the seminiferous tubules, which comprise about 90 percent of the testicular mass. T...