نتایج جستجو برای: terminal ligand
تعداد نتایج: 250827 فیلتر نتایج به سال:
The PSD-95/Discs-large/ZO-1 homology (PDZ) domain protein, protein interacting with C kinase 1 (PICK1) contains a C-terminal Bin/amphiphysin/Rvs (BAR) domain mediating recognition of curved membranes; however, the molecular mechanisms controlling the activity of this domain are poorly understood. In agreement with negative regulation of the BAR domain by the N-terminal PDZ domain, PICK1 distrib...
Cyclic nucleotides directly enhance the opening of the tetrameric CNG and HCN channels, although the mechanism remains unclear. We examined why HCN and certain CNG subunits form functional homomeric channels, whereas other CNG subunits only function in heteromeric channels. The "defect" in the CNGA4 subunit that prevents its homomeric expression was localized to its C-linker, which connects the...
Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism for switching on transcription of cognate target genes involves RAR binding at specific response elements and a network of interactions with coregulatory protein complexes, the assembly of which is directed by the C-termi...
The dinuclear title compound, [Co(2)Cl(3)(C(6)H(4)NO(2))(C(6)H(6)N(2)O)(2)(C(2)H(5)OH)], contains two six-coordinate Co(II) atoms with different octa-hedral coordination environments. One Co(II) atom is coordinated by two N atoms from one pyridine-2-carbaldehyde oxime ligand, by one terminal and one bridging Cl(-) ion, by one O atom from an ethanol mol-ecule, and by one O atom from a bridging p...
In the title organometallic polymer, [HgCl(2)(C(26)H(20)NO(3)P)](n), the monodentate 1-(3-nitro-phen-yl)-2-(triphenyl-phospho-ran-yl--idene)ethanone ligand is coordinated to the Hg(II) atom through the methine C atom. The Hg(II) atom is four-coordinated in a distorted tetra-hedral geometry by one terminal Cl atom, two bridging Cl atoms, and one C atom from the ylidic ligand, resulting in a poly...
Signal transduction events are often mediated by small protein domains such as SH2 (Src homology 2) domains that recognize phosphotyrosines (pY) and flanking sequences. In case of the SHP-2 receptor tyrosine phosphatase an N-terminal SH2 domain binds and inactivates the phosphatase (PTP) domain. The pY-peptide-binding site on the N-terminal SH2 domain does not overlap with the PTP binding regio...
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