It has been suggested that there is a link between epinephrine synthesis and the development of β2-adrenoceptor-mediated effects, but it remains to be determined whether this development is triggered by epinephrine. The aim of this study was to characterize β-adrenoceptor-mediated relaxation and facilitation of norepinephrine release in the aorta of phenylethanolamine-N-methyltransferase-knocko...

It has been suggested that there is a link between epinephrine synthesis and the development of b2-adrenoceptor–mediated effects, but it remains to be determined whether this development is triggered by epinephrine. The aim of this study was to characterize b-adrenoceptor–mediated relaxation and facilitation of norepinephrine release in the aorta of phenylethanolamine-Nmethyltransferase–knockou...

BACKGROUND AND AIMS The subtype and species related heterogeneity of beta adrenoceptors prompted a functional reappraisal of these molecular targets of motility inhibition in the human colon. METHODS Relaxation of muscle strips was measured in vitro. RESULTS The following agonists had decreasing relaxing potency (effective concentration range 10(-8)-10(-4) mol/l): (-)isoprenaline (non-selec...

Different beta 1 and 2 adrenergic receptor agonists may be various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta 2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion ratio, concentration of biochemical parameters in...

Drs. Elliott and Morrison recently published a narrative review about the effectiveness of oral and subcutaneous maintenance of tocolytic agents following successful arrest of acute preterm labor [1]. The authors conclude that subcuta-neous terbutaline pump is beneficial and safe for maintenance of tocolysis based on all the available evidence. While the authors have provided an exhaustive list...

BACKGROUND Inhaled adenosine monophosphate (AMP) is thought to cause bronchoconstriction in asthmatic patients indirectly through mast cell mediator release. It may therefore be a more sensitive marker of airway inflammation in asthma and hence more specific for epidemiological surveys of asthma than challenges that act directly on airway smooth muscle such as histamine. There is some uncertain...

Different beta 1 and 2 adrenergic receptors agonists might have various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion rate, concentration of biochemical parameters...

Short-acting 2-agonists (SABA) are used in asthma and chronic obstructive pulmonary disease (COPD) treatment because of their capacity to relax smooth muscle, their rapid symptoms relief and their acceptable safety profile. Salbutamol and terbutaline are the most frequently used SABA. Although SABA present an acceptable safety profile as above-mentioned, several adverse effects have been descri...