BACKGROUND The risk of upper gastrointestinal (GI) complications associated with the use of NSAIDs is a serious public health concern. The risk varies between individual NSAIDs; however, there is little information on the risk associated with some NSAIDs and on the impact of risk factors. These data are necessary to evaluate the benefit-risk of individual NSAIDs for clinical and health policy d...

ISSN © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. Dear Editor, Sugammadex is a modifi ed gamma cyclodextrin . Cyclodextrins are water soluble cyclic oligosaccharides with a lipophilic core. Sugammadex has quickly found a place in clinical use for selective antagonism of neuromuscular blockade with rocuronium . Sugammadex quickly encapsulates steroidal neuro...

Curcumin is coming from the Curcuma longa which gives golden color and have the biological importance. As per the survey it is water insoluble, the poor solubility and wettability of curcumin leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using di...

The aim of the study was to identify the types and frequency of errors during the administration of intravenous medication. A Cross-sectional, observational study was carried out in three units of a hospital. Observations were conducted on 367 doses of intravenous medication, prepared by 35 nurse technicians. Data collection took place between January and August of 2008. Errors were grouped in ...

BACKGROUND Osteoarthritis(OA) is the most common rheumatic disease. Simple analgesics are now accepted as the appropriate first line pharmacological treatment of uncomplicated OA. Non-aspirin NSAIDs are licensed for the relief of pain and inflammation arising from rheumatic disease. OBJECTIVES To determine whether there is a difference in the relative efficacy of individual non-steroidal anti...

215 words Introduction: 1170 words Main text: 5045 words Conclusions: 390 words References: 98 Number of tables: 1 This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on August 23, 2005 as DOI: 10.1124/dmd.105.006452 at A PE T Jornals on Jne 0, 2017 dm d.aspurnals.org D ow nladed from DMD 6452 (Revised) 3 Abbreviations:...

The market withdrawals of rofecoxib (Vioxx) and valdecoxib (Bextra) have focused considerable attention on the side effect profiles of cyclooxygenase (COX) inhibitors. As a result, attempts will be made to identify risk factors in the hope that physicians might be able to ensure patient safety. At first glance, CYP2C9 genotype might be considered a risk factor because many COX inhibitors are CY...

Objectives: The present study aimed to investigate the postoperative (PO) analgesic efficacy of intraperitoneal (IP) levobupivacaine instillation on the frequency and intensity of shoulder tip pain (STP) and its impact on duration of hospital stay in patients assigned for laparoscopic cholecystectomy (LC) comparing preemptive (PE) versus postoperative instillation. Patients & Methods: The study...