The circulating renin-angiotensin system (RAS), including the biologically active angiotensin II, is a fundamental regulatory mechanism of blood pressure conserved through evolution. Angiotensin II components of the RAS have also been identified in the brain. In addition to pro-inflammatory cytokines, neuromodulators, such as angiotensin II can induce (through angiotensin type 1 receptor (AT1R)...

PURPOSE To determine the role of angiotensin II type 1 receptor (AT1R) signaling in corneal neovascularization. METHODS Corneal neovascularization was induced by suturing 10-0 nylon 1 mm away from limbal vessels in C57 BJ6 mice. Angiotensinogen and its receptor (AT1R) gene expression levels were evaluated by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). The expres...

BACKGROUND Adiponectin is secreted by adipose tissue and may play a role in cardiovascular disease. We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs. Ramipril in Renal Endothelial Dysfunction (TRENDY) study. METHODS A total of 87 patients were assessed at baseline and following 9 weeks treatment with the angiotensin-receptor blocker telmis...

BACKGROUND Despite the known risk of diabetes-induced cardiac fibrosis, less is known about whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Peroxisome proliferator-activated receptor δ (PPARδ), a versatile regulator of metabolic homeostasis, may be a potential therapeutic target. Herein we investigated the effectiveness of telmisartan, a unique angi...

BACKGROUND A novel MRI technique, employing dual contrast manganese-enhanced MRI (MEMRI) and delayed enhancement MRI (DEMRI), can evaluate the physiologically unstable peri-infarct region. Dual contrast MEMRI-DEMRI enables comprehensive evaluation of telmisartan to salvage the peri-infarct injury to elucidate the underlying mechanism of restoring the ischemic cardiomyopathy in the diabetic mous...

Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravimetric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Ci...

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of telmisartan in serum samples. Isocratic elution at a flow rate of 1.0ml/min was employed on a Equsil, 250 X 4.6mm, 5μ at ambient temperature. The mobile phase consisted of buffer: Acetonitrile (35:65) (V/V). The UV detection wavelength was 282nm and 20μl sample was injected. The reten...

BACKGROUND Blood pressure (BP) has a circadian pattern with a morning surge that is associated with an increased risk of acute coronary and cerebrovascular events. In a prospective, randomized, open-label, blinded-endpoint, parallel-group, multicenter, forced-titration study of telmisartan and ramipril, the efficacy of both drugs on mean ambulatory diastolic BP (DBP) and systolic BP (SBP) durin...

An accurate and precise liquid chromatographic method was developed for the simultaneous estimation of telmisartan and metoprolol succinate in tablets. The chromatographic analysis was performed on Nucleosil C18 Column (250*4.6mm 5μ particle size) with mobile phase consisting of acetonitrile and potassium di-hydrogen orthophosphate buffer (pH2.8) in the ratio 60:40v/v, at a flow rate of 0.8ml/m...

BACKGROUND Angiotensin type 1 receptor (AT(1)R) blockers (ARB) have been shown to reduce the incidence of type 2 diabetes mellitus by an unknown molecular mechanism. The peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of insulin and glucose metabolism improving insulin sensitivity. We investigated the regulation of PPARgamma function by ARBs. METHODS AND ...