The ischemia-reperfusion-induced damage in human brain microvascular endothelial cells (BMECs) is associated with disruption of the blood–brain barrier. CXC chemokine ligand 5 (CXCL5) reported to be up-regulated ischemic stroke. However, detailed function CXCL5 this pathological process remains largely unclear. To further analyze stroke, an oxygen–glucose deprivation model on BMECs was construc...

1. Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008: 27: 5497–5510. 2. Lindhurst MJ, Sapp JC, Teer JK et al. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med 2011: 365: 611–619. 3. Kurek KC, Luks VL, Ayturk UM et al. Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. Am J Hum Genet 2012: 90: 11...

Laurate (C 12 )-sucrose esters are established intestinal epithelial permeation enhancers (PEs) with potential for use in oral delivery. Most studies have examined blends of ester rather than specific monoesters, little variation on the sugar moiety. To investigate influence varying moiety monoester performance, we compared three monoesters: C -sucrose, -lactose, and -trehalose. The assays were...

Abstract Introduction Transcatheter Edge-to-Edge repair (TEER) for mitral regurgitation (MR) is a minimal invasive alternative to surgery high risk patients. One of the principal disadvantage creating stenosis (MS). The optimal parameter and its cut-off monitor valve area (MVA) during TEER currently not defined usually only mean transmitral gradient (Gd) used. Method 116 patients with complete ...

In response to demand for innovative in vitro models for central nervous system disease and treatment we previously reported the microfluidic blood-brain barrier (μBBB). To further investigate shear stress, a key factor distinguishing the μBBB from traditional models, we substituted the top channel with independently monitored channel arrays to aid in high-throughput analysis. Optimal trans-end...

Abstract Background Human organoid-based intestinal monolayer cultures provide an interesting tool to preclinically assess new therapeutic properties in inflammatory bowel disease (IBD). Recently, short-chain fatty acids (SCFA) such as acetate and butyrate have gained interest for their potential beneficial effects IBD therapy. Most studies focused on butyrate, given its gut microbiome composit...

among the drug delivery and targeting (ddt) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. however, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. thus, in the current study, impact of dexamethason...

BackgroundMucopolysaccharide polysulfate (MPS) is a heparinoid and MPS-containing formulations are widely used as moisturizers for dry skin to treat peripheral vascular insufficiency. Although MPS has therapeutic effects in diseases with microvascular abnormalities, the of on function remain incompletely understood.ObjectiveThe aim this study was evaluate functional activities human pericytes (...

BackgroundSevere mitral regurgitation is a progressive disease associated with high morbidity and mortality, frequent readmissions for heart failure. Surgical valve repair or replacement has been the gold-standard treatment; however, advances in transcatheter edge-to-edge (TEER) have provided alternatives high-risk surgical patients. There are no data on racial disparities access to high-volume...