bone involvement. Destruction is mediated through normal osteoclasts, which respond to local osteoclast-activating microenvironment [7]. Technetium-99m 2methoxyisobutylisonitrile (TC-99m MIBI) is a lipophilic agent that accumulates within living malignant cells due to the higher transmembrane electrical potential as a consequence of the higher metabolic rate than in the surrounding normal cells...

Two pediatric cases are described in which the results of each patient's bone scan demonstrated abnormal stomach uptake. There have been a number of reports in the literature describing stomach uptake of bone agents, however, it is an uncommon finding.

UNLABELLED The purpose of this investigation was to develop and evaluate a new and rapid miniaturized chromatography system that would accurately assess the radiochemical purity of 99mTc-tetrofosmin without the problems of solvent ratios and time requirements associated with the manufacturer's recommended procedure. METHODS The migration of the radiochemical components of 99mTc-tetrofosmin wa...

Technetium-99m (Tc-99m) teboroxime is a new perfusion tracer that is highly extracted and rapidly cleared by the myocardium. To determine the feasibility of Tc-99m teboroxime imaging in the diagnosis of patients with suspected coronary artery disease, 30 patients underwent single photon emission computed tomography imaging with Tc-99m teboroxime (25.2 +/- 1 mCi) at peak exercise and again 60 mi...

5. Stokely EM, Buja M, Lewis SE, Parkey RW, Bonte FJ, Harris RA, Willerson JT: Measurement of acute myocardial infarcts in dogs with '9mTc-stannous pyrophosphate scintigrams. J Nucl Med 17: 1, 1976 6. Bruno F, Cobb FR, Rivas F, Bache RJ, Goodrich JK: Sequential "Tc pyrophosphate imaging of acute myocardial infarction in awake dogs. (abstr) Circulation 49 and 50 (suppl III): 111-104, 1974 7. Buj...

To the Editor, We report a 52-year-old male patient with bone marrow and skeletal system involvement of sarcoidosis. In sarcoidosis, while bone involvement occurs at a rate of 10%-15%, iliac bone and bone marrow involvement is less common [1,2]. A 52-year-old male patient was admitted to our clinic with increased lower back pain with activity for the last 2 months. The patient occasionally coug...

A 3 years old boy with a history of surgery for orchidopexy was admitted to our hospital with fever and abdominal pain. Clinical examination and laboratory investigations revealed urinary tract infection with renal involvement. Ultrasonography demonstrated a solitary left kidney and raised the suspicion of a fusion anomaly. Voiding cystography disclosed grade III vesicoureteral reflux and tec...

The detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to single-photon emission computed to...

Since the first tracer study by George C. de Hevesy in 1923, in which he used the tracer principle to study the absorption and translocation of lead nitrate with Pb-212 (1), radionuclides have been used both in vitro and in vivo to trace various biologic processes. The radioisotopes of iodine in particular have played an important role in the early development of nuclear medicine since their us...

Localization of the placenta by means of technetium-99m and a portable scintillation counter and ratemeter proved to be both simple and accurate. It could be performed by resident obstetric staff with minimal technical knowledge, and the radiation dosage was low.