Increasing dependence of business on 24/7 IT systems sets requirements to support recovery from hardware, software and operational errors and reduce number and length of maintenance windows through online and automated or semi-automated system management activities. These requirements cannot be satisfied purely by technology let alone a single technological innovation on a single layer of a sys...

The security of two message authentication code (MAC) algorithms is considered: the MD5-based envelope method (RFC 1828), and the banking standard MAA (ISO 8731–2). Customization of a general MAC forgery attack allows improvements in both cases. For the envelope method, the forgery attack is extended to allow key recovery; for example, a 128-bit key can be recovered using 2 known text-MAC pairs...

Degeneration of primary spermatocytes by apoptosis occurs during normal spermatogenesis, as well as in several pathological conditions, including exposure to specific testicular toxicants. The mechanisms that regulate the death and survival of primary spermatocytes, however, are still not well understood. The recent localization of estrogen receptor beta (ERbeta) and P450 aromatase in pachytene...

IMPORTANCE Quality and safety of eyedrop use for patients treated in a health care setting play a vital role in the delivery of health care. OBJECTIVE To describe the development of a policy and procedural approach to the use of multidose eyedrops in multiple patients, approved and accepted by The Joint Commission in compliance with preferred practice standards in ophthalmology, the safe hand...

Model Accuracy Assessment (MAA) is an important part of the modern verification and validation process. This involves not only evaluation of a validation metric comparing experimental versus simulation system response quantities, but also the determination of the adequacy of the model for its intended use (see [1] for a detailed description). We describe here some issues related to the use of p...

Exposures to sufficiently high doses of ethylene glycol monomethyl ether (2-methoxyethanol, 2-ME) have been found to produce developmental effects in rodents and nonhuman primates. The acetic acid metabolite of 2-ME, 2-methoxyacetic acid (2-MAA), is the likely toxicant, and, as such, an understanding of the kinetics of 2-MAA is important when assessing the potential risks to humans associated w...

This study was conducted to determine the prevalence of PE in patients with V/Q scans interpreted as representing a very low probability (VLP) of PE (1-3 small segmental perfusion defects with a normal chest radiograph). An analysis of the entire data set obtained during the PIOPED study was performed. Of the total of 1,359 patients in whom the presence or absence of PE was confirmed, 80 ...

Poly(ethylene glycol) dimethacrylate (PEGDMA) and methacrylic acid (MAA) based micro and nanoparticles were prepared for oral insulin delivery. The reactional profiles of MAA, PEGDMA and PEGDMA-MAA were elucidated using molecular mechanics energy relationships (MMER) in vacuum and in a solvated system by exploring the spatial disposition of different concentrations of polymers with respect to e...