Traumatic brain injury (TBI) results in the generation of tau. As hyperphosphorylated tau (p-tau) is one major consequences TBI, targeting p-tau TBI may lead to development new therapy. Twenty-five pigs underwent a controlled cortical impact. One hour after were administered either vehicle (n = 13) or PNT001 12), monoclonal antibody for cis conformer phosphorylated at threonine 231. Plasma biom...

Traumatic brain injury (TBI) is a well recognized public health problem worldwide. TBI has previously been considered as a rare cause of hypopituitarism, but an increased prevalence of neuroendocrine dysfunction in patients with TBI has been reported during the last 15 years in most of the retrospective and prospective studies. Based on data in the current literature, approximately 15%-20% of T...

This study examined the proportion of men and women reporting previous traumatic brain injury (TBI) in an Ontario (Canada) prison sample by demographic characteristics; adverse life experiences; and criminal, drug, and alcohol use history. Using data from The Cost of Substance Abuse in Canada study based on a random sample from four Ontario prisons, this study found 50.4% of males and 38% of fe...

OBJECTIVE Determine the effect of moderate and severe traumatic brain injuries (TBI) on the sleep of school-aged children. METHODS A concurrent cohort-prospective design compared children aged 6-12 years who sustained moderate TBI (baseline n = 56), severe TBI (n = 53), or only orthopedic injuries (n = 80). Retrospective parental report of pre-injury sleep was collected about 3 weeks post-inj...

Clinical studies have shown that probiotics influence gastrointestinal motility. However, the molecular mechanisms by which probiotic Lactobacillus modulates intestinal motility in traumatic brain injury (TBI) mouse model have not been explored. In the present study, we provided evidence showing that treatment of TBI mice with Lactobacillus acidophilus significantly improved the terminal ileum ...

The pathology and sequelae of pediatric traumatic brain injury (TBI) differ from those of the adult TBI population. In childhood TBI, cognitive impairment and secondary delays are often overlooked in the referral and intervention process. Although TBI is the leading cause of acquired disability in childhood, most children with TBI are discharged from acute care to home with little or no rehabil...

Traumatic brain injury (TBI) is a critical cause of hospitalization, disability, and death worldwide. The global increase in the incidence of TBI poses a significant socioeconomic burden. Guidelines for the management of acute TBI mostly pertain to emergency treatment. Comprehensive gene expression analysis is currently available for several animal models of TBI, along with enhanced understandi...

Traumatic brain injury (TBI) is currently a rising player in the cause of disability and neurological dysfunction worldwide. TBI common occurrence military extreme activities, sports arena accidents. Severe can be fatal but mild persists progressively deteriorates homeostasis physiology. Apart from physical disabilities, psychological complexities arise people with TBI. Despite seriousness this...

ObjectiveThe aim of this manuscript is to compare characteristics, management, and outcomes patients with severe Traumatic Brain Injury (TBI) between Australia, the United Kingdom (UK) Europe.MethodsWe enrolled TBI in Victoria, Australia (OzENTER-TBI), UK Europe (CENTER-TBI) from 2015 2017. Main outcome measures were mortality unfavourable (Glasgow Outcome Scale Extended <5) 6 months after inju...

To investigate the role of Trim32 in traumatic brain injury (TBI), adult male Sprague Dawley (SD) rats and mice were randomly divided into sham (n = 6) and TBI groups ( n = 24), respectively. Then, mice were assigned into Trim32 knockout mice (Trim32-KO [+/-]) and wild-type (WT) littermates. The TBI model used was the Feeney free-falling model, and neurological function was evaluated after TBI ...