Isopropyl (IPLA), N-methyl-N-isopropyl (MIPLA), N-ethyl-N-isopropyl (EIPLA), and N,N-diisopropyl (DIPLA) lysergamides were evaluated for lysergic acid diethylamide (LSD)-like activity. In rats trained to discriminate 0.08 mg/kg LSD tartrate from saline, each of the subject compounds completely substituted, with an ED50 two to three times larger than that of LSD except for DIPLA, which had an ED...

Background It has been suggested that carbohydrate-protein based multi-ingredient supplements may attenuate exercise induced muscle damage (EIMD) and immunosuppression. This study investigates the effects of a commercially available carbohydrate-protein supplement (MTN) enriched with L-glutamine, L-carnitine-L-tartrate compared to carbohydrate alone (CHO) or placebo (PL), on sprint performance,...

Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment. The mimetic peptide, DN59, consists of residues corresponding to the membrane interacting, amphipathic stem region of the dengue virus envelope (E) glycoprotein. This peptide is inhibitory to all four serotypes of dengue virus, as well as other flaviviruses. Cryo-electron microscopy ...

E-beam and gamma products from the radiolysis of aqueous solutions of (7)-metoprolol tartrate, saturated in nitrogen, are analyzed by HPLC with on-line mass and UV detectors. The structures of 10 radiolytic products common to e-beam and gamma irradiations are elucidated by comparing their fragmentation pattern to that of (7)-metoprolol. Two of the radiolytic products are also metabolites. Diffe...

The increased isocitrate consumption of isolated rat liver mitochondria brought about by the addition of L-malate is quantitatively accounted for by increases in the production of both a-ketoglutarate and citrate. The effect on citrate production is still observed under conditions such that the oxidation of isocitrate to a-ketoglutarate is completely inhibited. The specificity of the effect has...

A total of 24,591 nonhuman salmonella strains isolated in Germany between 1986 and 1998 were examined for their resistance to nalidixic acid by an agar diffusion method. The rate of resistance (inhibition zone, </=13 mm) ranged from 0.2% in 1986 to a peak of 14. 8% in 1990. Between 1991 and 1998 the MICs for nalidixic acid-resistant strains ranged from more than 256 microg/ml for nalidixic acid...

The (R)- and (S)-2-butylamides of d-lysergic acid were prepared and evaluated in behavioral and biochemical assays of 5-HT2 agonist activity. In rats trained to discriminate 0.08 mg/kg LSD tartrate from saline, both isomers completely substituted for the training stimulus. Similarly, both isomers were found to possess very high affinity in displacing [125I]-(R)-DOI ([125I]-(R)-1-(2,5-dimethoxy-...

An amperometric acetone sensor was developed by using an electrodeposited Pb electrode in a sodium tartrate electrolyte. The major factors determining the electrode and sensing characteristics such as the applied potential, electrodeposition current density, electrodeposition temperature, agitation rate, and sensing temperature were explored. The best conditions for preparation of the electrode...

The B-IV and B-IX zonal ultracentrifuge rotors were applied to the concentration and purification of the Moloney and Rauscher murine leukemia viruses from large volumes of infected tissue culture fluids and animal materials. Potassium tartrate, potassium citrate and sucrose gradients were used to obtain viral concentrates from the density 1.16 to 1.18 zone. Proteolytic enzyme digestion of tissu...

Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid ...