Diazepam, an antianxietic agent, antagonized the stress-induced analgesia (SIA) distinctively depending on the characteristics of the stress. Psychological (PSY, using communication box)-SIA was completely blocked by 1 or 2 mg/kg of diazepam in the tail pinch (TP) method, but not antagonized by 1 mg/kg of the drug in the tail flick test. Swimming-SIA was resistant to diazepam in both methods an...

  Pharmacologists believe analgesic and anti-inflammatory drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and opioid compounds, due to their side-effects and, in some cases, inadequacy, are not always useful. Therefore it seems necessary to search for newer analgesic compounds. In traditional Iranian Medicine, the leaf and rhizome of Sambucus ebulus is used as a topical medication ...

Extracts obtained from the petals of Rosa damascena (Rosaceae) are used in Iranian folk medicine as remedies for the treatment of some inflammatory diseases. In this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. The extract was administered at the doses (p.o.) of 250, 500 and 1000?mg/kg and the dose...

Extracts obtained from the petals of Rosa damascena (Rosaceae) are used in Iranian folk medicine as remedies for the treatment of some inflammatory diseases. In this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. The extract was administered at the doses (p.o.) of 250, 500 and 1000?mg/kg and the dose...

The responsiveness to noxious thermal, mechanical, and chemical stimuli was examined in adult rats that had been treated neonatally with capsaicin. A range of capsaicin doses was employed to determine whether the neurotoxicity of capsaicin to primary afferent fibers would be manifested behaviorally in a selective effect on nociceptive thresholds to specific stimuli. Animals were given 5 to 100 ...

Argyreia speciosa (Convolvuceae) is regarded as a ‘Rasayan’ drug in the ayurvedic system of medicine to cure diseases of nervous system. Sphearanthus indicus is known as nervine tonic and used for relief of pain in Indian traditional system of medicine. In the present study an attempt was made to evaluate the analgesic and anti-inflammatory activity of hydroalcoholic extract of Argyreia specios...

Extracts obtained from the petals of Rosa damascena (Rosaceae) are used in Iranian folk medicine as remedies for the treatment of some inflammatory diseases. In this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. The extract was administered at the doses (p.o.) of 250, 500 and 1000 mg/kg and the dose...

OBJECTIVE We compared the effects of 2 sedative drugs, dexmedetomidine and midazolam, on motor performance and analgesic efficacy in a rat model. MATERIALS AND METHODS Rats were randomly divided into the following 4 groups on the basis of the treatment received. The first group received 83 µg/kg/min midazolam; the second, 1 µg/kg/min dexmedetomidine; the third, 83 µg/kg/min morphine; and the ...