The ayurvedic pharmacy needs to be established on the basis of modern quality standards. A study on ayurvedic Guti-Vati (tablets) was undertaken with this view, revealed that most of the tablets conform to the I P standards for hardness and DT. A few of the tablets showed curious responses similar to that of enteric coated and slow release tablets commonly used in modern medicine.A systematic s...

The present research aims to test the hypothesis that the addition of a minor component causes a change in pore shape in the matrix of the primary component, causing a decrease in mechanical strength. Tablets made of sodium chloride only and tablets made of a mixture of sodium chloride (97.5% v/v) and starch (2.5% v/v) were compared. Tablets were subjected to a heat treatment to remove the star...

The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. The in vitro drug release study...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. Drug release from hot-melt extruded (HME) tablets containing either chitosan or xanthan gum was pH and buffer species dependent and the release ...

Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxypropyl methylcellulose (HPMC K4M, HPMC K100M) and xanthan gum. Tablets were evaluated for their physical characteristics, viz., hardness, thickness, friability, and mass vari...

The aim of the current investigation is to study the kinetics of drug release pattern from buccal swellable, controlled release tablets of amoxicillin trihydrate. Buccal tablets were prepared with modified gum karaya in 5-20% concentration. Drug release from the formulated amoxicillin trihydrate loaded buccal tablets followed Zero order kinetics resulting in regulated and controlled release for...

The aim of this work was to explore the possibility of utilizing BFI as a tool for classifying, grouping and ranking binders based on performance in ameliorating capping and lamination in paracetamol tablets. Binders from different origins (starches, celluloses, natural gums, and synthetic gums) were used via wet granulation at concentrations ranging from 1.0 12.5% w/w to make paracetamol table...

Omeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three mucoadhesive polymers namely hydroxypropylemethylcellulose K4M, sodium carboxy methylcellulose, carbopol-934P and ethyl cellulose were used for preparation of tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active duodenal ulcer. Mucoadhes...

The objective of present study was to evaluate the effect of processing methods and sintering condition on matrix formation and subsequent drug release from wax matrix tablets for controlled release. Ketorolac tromethamine and compritol were processed with appropriate diluent using either dry blending, spray drying, partial melt granulation or melt granulation.The tablets were then sintered at ...

A series of six palatability studies, employing acceptance (three studies) and preference (three studies) tests, were used to compare the voluntary acceptance, preference and consumption of a palatable formulation of carprofen (Rimadyl® Chewable Tablets or Rimadyl® Palatable Tablets; Pfizer Animal Health) with those of two generic formulations of carprofen (Carprodyl® Tablets; Ceva and Norocarp...